ENSG00000196405


Homo sapiens

Features
Gene ID: ENSG00000196405
  
Biological name :EVL
  
Synonyms : Enah/Vasp-like / EVL / Q9UI08
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 99971449
Gene end: 100144236
  
Corresponding Affymetrix probe sets: 217838_s_at (Human Genome U133 Plus 2.0 Array)   227232_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452156
Ensembl peptide - ENSP00000451821
Ensembl peptide - ENSP00000452327
Ensembl peptide - ENSP00000481825
Ensembl peptide - ENSP00000376652
Ensembl peptide - ENSP00000384720
Ensembl peptide - ENSP00000437904
Ensembl peptide - ENSP00000450723
Ensembl peptide - ENSP00000450979
Ensembl peptide - ENSP00000451226
Ensembl peptide - ENSP00000451761
NCBI entrez gene - 51466     See in Manteia.
OMIM - 616912
RefSeq - XM_017021364
RefSeq - NM_001330221
RefSeq - NM_016337
RefSeq - XM_005267749
RefSeq - XM_011536828
RefSeq - XM_017021363
RefSeq Peptide - NP_057421
RefSeq Peptide - NP_001317150
swissprot - H0YJN0
swissprot - Q9UI08
swissprot - A0A024R6K5
swissprot - A0A087WYI2
swissprot - G3V2K5
swissprot - G3V314
swissprot - G3V3G2
swissprot - G3V5F7
swissprot - G3V535
swissprot - H0YJL6
Ensembl - ENSG00000196405
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 evlaENSDARG00000035650Danio rerio
 EVLENSGALG00000011209Gallus gallus
 EvlENSMUSG00000021262Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENAH / Q8N8S7 / ENAH, actin regulatorENSG0000015438054
VASP / P50552 / vasodilator stimulated phosphoproteinENSG0000012575344
Q2MJR0 / SPRED3 / sprouty related EVH1 domain containing 3ENSG0000018876618
Q7Z698 / SPRED2 / sprouty related EVH1 domain containing 2ENSG0000019836917
Q7Z699 / SPRED1 / sprouty related EVH1 domain containing 1ENSG0000016606817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000697  WH1/EVH1 domain
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR014885  VASP tetramerisation
 IPR017354  Vasodilator-stimulated phosphoprotein/ENA/VASP-like
 IPR034319  ENA/VASP-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization TAS
 biological_processGO:0007166 cell surface receptor signaling pathway NAS
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0009887 animal organ morphogenesis NAS
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:1900028 negative regulation of ruffle assembly IMP
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISS


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Signaling by ROBO receptors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000196588 MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction / complex
 ENSG00000196405 EVL / Q9UI08 / Enah/Vasp-like  / complex
 ENSG00000131504 DIAPH1 / O60610 / diaphanous related formin 1  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr