ENSMUSG00000008090


Mus musculus

Features
Gene ID: ENSMUSG00000008090
  
Biological name :Fgfrl1
  
Synonyms : Fgfrl1 / Fibroblast growth factor receptor-like 1 / Q91V87
  
Possible biological names infered from orthology : Q8N441
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 108692382
Gene end: 108706924
  
Corresponding Affymetrix probe sets: 10524052 (MoGene1.0st)   1447878_s_at (Mouse Genome 430 2.0 Array)   1451912_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142430
Ensembl peptide - ENSMUSP00000143037
Ensembl peptide - ENSMUSP00000013633
Ensembl peptide - ENSMUSP00000108179
NCBI entrez gene - 116701     See in Manteia.
MGI - MGI:2150920
RefSeq - NM_054071
RefSeq - XM_017320618
RefSeq - NM_001164259
RefSeq Peptide - NP_001157731
RefSeq Peptide - NP_473412
swissprot - A0A0G2JDM8
swissprot - Q91V87
swissprot - A0A0G2JF62
Ensembl - ENSMUSG00000008090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgfrl1aENSDARG00000032617Danio rerio
 FGFRL1ENSGALG00000037525Gallus gallus
 FGFRL1ENSG00000127418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0003179 heart valve morphogenesis IMP
 biological_processGO:0007166 cell surface receptor signaling pathway ISA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IC
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060539 diaphragm development IMP
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 molecular_functionGO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity ISA
 molecular_functionGO:0005007 fibroblast growth factor-activated receptor activity IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017134 fibroblast growth factor binding IPI


Pathways (from Reactome)
Pathway description
FGFRL1 modulation of FGFR1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000071 axial skeleton hypoplasia "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000104 abnormal sphenoid bone morphology "malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000440 domed skull 
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002258 abnormal cricoid cartilage morphology "any structural anomaly of the most inferior of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002260 abnormal thyroid cartilage morphology "any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004447 small basioccipital bone "reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004462 small basisphenoid bone "reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm3Pch/Egr2tm3Pch,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Fgfrl1tm2.1True/Fgfrl1tm2.1True
Genetic Background: B6.Cg-Fgfrl1tm2.1True

Allelic Composition: Fgfrl1tm2.1True/Fgfrl1+
Genetic Background: B6.Cg-Fgfrl1tm2.1True

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004572 fusion of basioccipital and basisphenoid bone "union of the basioccipital and basisphenoid bones into one structure, when this fusion does not normally occur (such as in a species where these bones normally persist as separate entities)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0004734 small thoracic cavity "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0009384 cardiac valve regurgitation "the backward reflux of blood through a cardiac valve, due to insufficiency caused by disease, aging or congenital malformation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0009912 decreased hyoid bone size "reduced size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010941 abnormal foramen magnum morphology "any structural anomaly of the large orifice in the occipital bone through which the spinal cord passes to the cranial cavity and becomes continuous with the medulla oblongata" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0010987 abnormal nephrogenic mesenchyme morphogenesis "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing nephron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0011177 abnormal erythroblast number "altered number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0011292 absent nephron "complete absence of functional filtering units in the kidney" [MGI:anna]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0012085 midface hypoplasia "underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: PhbGt(BGB069)Byg/Phb+
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0012514 pectus excavatum "a caved-in or sunken appearance of the anterior chest wall; the congenital deformity can either be present at birth or may not be visible until puberty" [MGI:anna]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Fgfrl1tm1.1Ptew/Fgfrl1tm1.1Ptew
Genetic Background: B6.129-Fgfrl1tm1.1Ptew

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000008090 Fgfrl1 / Q91V87 / Fibroblast growth factor receptor-like 1 / Q8N441*  / complex
 ENSMUSG00000027351 Q924S8 / Spred1 / Sprouty-related, EVH1 domain-containing protein 1 / Q7Z699* / sprouty related EVH1 domain containing 1*  / reaction / complex
 ENSMUSG00000045671 Q924S7 / Spred2 / Sprouty-related, EVH1 domain-containing protein 2 / Q7Z698* / sprouty related EVH1 domain containing 2*  / reaction / complex






 

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