ENSMUSG00000024456


Mus musculus

Features
Gene ID: ENSMUSG00000024456
  
Biological name :Diaph1
  
Synonyms : 1 / Diaph1 / O08808
  
Possible biological names infered from orthology : diaphanous related formin 1 / O60610
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 37843601
Gene end: 37935476
  
Corresponding Affymetrix probe sets: 10458430 (MoGene1.0st)   1421143_at (Mouse Genome 430 2.0 Array)   1445391_at (Mouse Genome 430 2.0 Array)   1454979_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111297
Ensembl peptide - ENSMUSP00000078942
Ensembl peptide - ENSMUSP00000111292
Ensembl peptide - ENSMUSP00000111294
Ensembl peptide - ENSMUSP00000025337
NCBI entrez gene - 13367     See in Manteia.
MGI - MGI:1194490
RefSeq - XM_011246826
RefSeq - NM_001305980
RefSeq - NM_001305981
RefSeq - NM_007858
RefSeq Peptide - NP_031884
RefSeq Peptide - NP_001292909
RefSeq Peptide - NP_001292910
swissprot - F6XC54
swissprot - E9PV41
swissprot - E9PXV7
swissprot - O08808
swissprot - D3Z074
Ensembl - ENSMUSG00000024456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01057928.1ENSDARG00000115082Danio rerio
 DIAPH1ENSG00000131504Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*ENSMUSG0000003448046
3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*ENSMUSG0000002202143
Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*ENSMUSG0000003457424
Daam2 / Q80U19 / Disheveled-associated activator of morphosis 2 / Q86T65* / dishevelled associated activator of morphogenesis 2*ENSMUSG0000004026023
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*ENSMUSG0000003767921
Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*ENSMUSG0000005580518
Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*ENSMUSG0000002300818
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*ENSMUSG0000003605318
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*ENSMUSG0000004184212


Protein motifs (from Interpro)
Interpro ID Name
 IPR009408  Formin Homology 1
 IPR010465  DRF autoregulatory
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027653  Formin, protein diaphanous homologue 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0032886 regulation of microtubule-based process IEA
 biological_processGO:0035372 protein localization to microtubule IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0071420 cellular response to histamine IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding IDA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins
ERBB2 Regulates Cell Motility
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Diaph1tm1Asal/Diaph1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Diaph1tm1Asal/Diaph1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Diaph1tm1Asal/Diaph1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Diaph1M2Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M2Btlr

Allelic Composition: Diaph1M1Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Diaph1M2Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M2Btlr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Foxn1nu-StL/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Diaph1M2Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M2Btlr

Allelic Composition: Diaph1M1Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Diaph1M2Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M2Btlr

Allelic Composition: Diaph1M1Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrfn2Tg(CD2-Myb/en)5Kmw/Lrfn2+,Tg(H2-K-Myc)1Brn/?
Genetic Background: involves: C57BL/10 * CBA * FVB/N

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Diaph1M2Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M2Btlr

 MP:0009949 abnormal olfactory bulb granule cell layer morphology 
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Allelic Composition: Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph2tm1.2Sna

Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Diaph1M1Btlr/Diaph1M1Btlr
Genetic Background: C57BL/6J-Diaph1M1Btlr

Allelic Composition: Diaph1M1Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

Allelic Composition: Diaph1M1Btlr/Diaph1M1Btlr
Genetic Background: C57BL/6J-Diaph1M1Btlr

Allelic Composition: Diaph1M1Btlr/Diaph1+
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Diaph1M1Btlr/Diaph1M1Btlr
Genetic Background: C57BL/6J-Diaph1M1Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000021262 Evl / P70429 / Ena/VASP-like protein / Q9UI08* / Enah/Vasp-like*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / reaction / complex
 ENSMUSG00000042292 Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*  / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction






 

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