ENSMUSG00000039542


Mus musculus

Features
Gene ID: ENSMUSG00000039542
  
Biological name :Ncam1
  
Synonyms : Ncam1 / neural cell adhesion molecule 1 isoform 3
  
Possible biological names infered from orthology : neural cell adhesion molecule 1 / P13591
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 49502136
Gene end: 49798925
  
Corresponding Affymetrix probe sets: 10593293 (MoGene1.0st)   1421966_at (Mouse Genome 430 2.0 Array)   1425126_at (Mouse Genome 430 2.0 Array)   1426864_a_at (Mouse Genome 430 2.0 Array)   1426865_a_at (Mouse Genome 430 2.0 Array)   1439556_at (Mouse Genome 430 2.0 Array)   1450437_a_at (Mouse Genome 430 2.0 Array)   1450438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110120
Ensembl peptide - ENSMUSP00000141700
Ensembl peptide - ENSMUSP00000130668
Ensembl peptide - ENSMUSP00000142331
Ensembl peptide - ENSMUSP00000142275
Ensembl peptide - ENSMUSP00000141730
NCBI entrez gene - 17967     See in Manteia.
MGI - MGI:97281
RefSeq - XM_017313201
RefSeq - XM_011242416
RefSeq - XM_017313192
RefSeq - XM_017313193
RefSeq - XM_017313194
RefSeq - XM_017313195
RefSeq - XM_017313196
RefSeq - XM_017313197
RefSeq - XM_017313198
RefSeq - XM_017313199
RefSeq - XM_017313200
RefSeq - NM_001081445
RefSeq - NM_001113204
RefSeq - NM_001311065
RefSeq - NM_010875
RefSeq - XM_006510055
RefSeq - XM_006510056
RefSeq - XM_006510057
RefSeq - XM_006510058
RefSeq - XM_006510059
RefSeq - XM_006510060
RefSeq - XM_006510061
RefSeq - XM_006510062
RefSeq - XM_006510063
RefSeq - XM_006510064
RefSeq - XM_006510065
RefSeq - XM_006510066
RefSeq - XM_006510067
RefSeq - XM_006510068
RefSeq - XM_006510069
RefSeq - XM_006510070
RefSeq - XM_006510071
RefSeq - XM_006510073
RefSeq - XM_006510074
RefSeq - XM_006510075
RefSeq - XM_011242413
RefSeq - XM_011242414
RefSeq - XM_011242415
RefSeq Peptide - NP_001074914
RefSeq Peptide - NP_001106675
RefSeq Peptide - NP_001297994
RefSeq Peptide - NP_035005
swissprot - A0A0A6YWW5
swissprot - E9QB01
swissprot - A0A0A6YWU2
swissprot - E9Q589
swissprot - A0A0A6YY91
swissprot - A0A0A6YY47
Ensembl - ENSMUSG00000039542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncam1aENSDARG00000056181Danio rerio
 ncam1bENSDARG00000007220Danio rerio
 NCAM1ENSGALG00000007839Gallus gallus
 NCAM1ENSG00000149294Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*ENSMUSG0000002276243
Robo1 / roundabout guidance receptor 1 / Q9Y6N7*ENSMUSG0000002288322
Robo2 / roundabout guidance receptor 2 / Q9HCK4*ENSMUSG0000005251621
Robo3 / roundabout guidance receptor 3 / Q96MS0*ENSMUSG0000003212820
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*ENSMUSG0000003811920
Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSMUSG0000002268718
Robo4 / roundabout guidance receptor 4 / Q8WZ75*ENSMUSG000000321259


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR009138  Neural cell adhesion
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR033019  Neural cell adhesion molecule 1
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
NCAM1 interactions
Signal transduction by L1
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: St8sia2tm1Jxm/St8sia2tm1Jxm,St8sia4tm1.1Mifu/St8sia4tm1.1Mifu,Tg(Thy1-YFP)HJrs/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: (129S1.Cg-Ucptm1Kz x B6.Cg-Ucptm1Kz)F1

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: (129S1.Cg-Ucptm1Kz x B6.Cg-Ucptm1Kz)F1

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Smad2tm1Enl/Smad2+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Ncam1tm1Mag/Ncam1tm1Mag
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Ncam1tm1Klc/Ncam1tm1Klc
Genetic Background: either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Ncam1tm1Klc/Ncam1tm1Klc
Genetic Background: either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Ncam1tm1Klc/Ncam1tm1Klc
Genetic Background: either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)

Allelic Composition: Ncam1tm1Klc/Ncam1+
Genetic Background: either: (involves: 129 * C57BL/6J) or (involves: 129 * CD-1)

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Ncam1tm1Mag/Ncam1tm1Mag
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: St8sia2tm1Jxm/St8sia2tm1Jxm,St8sia4tm1.1Mifu/St8sia4tm1.1Mifu,Tg(Thy1-YFP)HJrs/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ncam1tm1Mag/Ncam1tm1Mag
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Prkdcdxnph/Prkdcdxnph
Genetic Background: 129X1/SvJ

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Ncam1tm1Mag/Ncam1tm1Mag
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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