ENSG00000149294


Homo sapiens

Features
Gene ID: ENSG00000149294
  
Biological name :NCAM1
  
Synonyms : NCAM1 / neural cell adhesion molecule 1 / P13591
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.2
Gene start: 112961247
Gene end: 113278436
  
Corresponding Affymetrix probe sets: 209968_s_at (Human Genome U133 Plus 2.0 Array)   212843_at (Human Genome U133 Plus 2.0 Array)   214952_at (Human Genome U133 Plus 2.0 Array)   217359_s_at (Human Genome U133 Plus 2.0 Array)   227394_at (Human Genome U133 Plus 2.0 Array)   229799_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478072
Ensembl peptide - ENSP00000477835
Ensembl peptide - ENSP00000479241
Ensembl peptide - ENSP00000486406
Ensembl peptide - ENSP00000486241
Ensembl peptide - ENSP00000484943
Ensembl peptide - ENSP00000484481
Ensembl peptide - ENSP00000482852
Ensembl peptide - ENSP00000482205
Ensembl peptide - ENSP00000481083
Ensembl peptide - ENSP00000480797
Ensembl peptide - ENSP00000480774
Ensembl peptide - ENSP00000480269
Ensembl peptide - ENSP00000480132
Ensembl peptide - ENSP00000479687
Ensembl peptide - ENSP00000479353
Ensembl peptide - ENSP00000318472
Ensembl peptide - ENSP00000384055
Ensembl peptide - ENSP00000475074
Ensembl peptide - ENSP00000477808
NCBI entrez gene - 4684     See in Manteia.
OMIM - 116930
RefSeq - NM_181351
RefSeq - NM_000615
RefSeq - NM_001076682
RefSeq - NM_001242607
RefSeq - NM_001242608
RefSeq Peptide - NP_001070150
RefSeq Peptide - NP_851996
RefSeq Peptide - NP_001229536
RefSeq Peptide - NP_001229537
RefSeq Peptide - NP_000606
swissprot - A0A087WVD0
swissprot - A0A087WV75
swissprot - A0A087WTR3
swissprot - A0A087WTF6
swissprot - H7BYX6
swissprot - P13591
swissprot - A0A087WTE4
swissprot - A0A0D9SF98
swissprot - A0A0D9SF30
swissprot - A0A0C4DGS4
swissprot - A0A087WZS4
swissprot - A0A087X1V2
swissprot - A0A087WX77
swissprot - A0A087WWJ5
swissprot - A0A087WWD4
swissprot - A0A087WVU1
Ensembl - ENSG00000149294
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncam1aENSDARG00000056181Danio rerio
 ncam1bENSDARG00000007220Danio rerio
 NCAM1ENSGALG00000007839Gallus gallus
 Ncam1ENSMUSG00000039542Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCAM2 / O15394 / neural cell adhesion molecule 2ENSG0000015465442
ROBO1 / Q9Y6N7 / roundabout guidance receptor 1ENSG0000016985521
ROBO2 / Q9HCK4 / roundabout guidance receptor 2ENSG0000018500820
ROBO3 / Q96MS0 / roundabout guidance receptor 3ENSG0000015413420
CDON / Q4KMG0 / cell adhesion associated, oncogene regulatedENSG0000006430919
BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulatedENSG0000014485718
ROBO4 / Q8WZ75 / roundabout guidance receptor 4ENSG0000015413310


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR009138  Neural cell adhesion
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033019  Neural cell adhesion molecule 1
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
ECM proteoglycans
NCAM signaling for neurite out-growth
NCAM1 interactions
Signal transduction by L1
RAF/MAP kinase cascade
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000130287 NCAN / O14594 / neurocan  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / complex / reaction
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / complex / reaction
 ENSG00000125650 PSPN / O60542 / persephin  / reaction / complex
 ENSG00000188157 AGRN / agrin / O00468  / complex / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000132670 PTPRA / P18433 / protein tyrosine phosphatase, receptor type A  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / reaction / complex
 ENSG00000184144 CNTN2 / Q02246 / contactin 2  / reaction / complex
 ENSG00000006283 O43497 / CACNA1G / calcium voltage-gated channel subunit alpha1 G  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / complex / reaction
 ENSG00000196557 O95180 / CACNA1H / calcium voltage-gated channel subunit alpha1 H  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000171867 PRNP / P04156 / prion protein  / reaction / complex
 ENSG00000100346 Q9P0X4 / CACNA1I / calcium voltage-gated channel subunit alpha1 I  / complex / reaction






 

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