ENSG00000130287


Homo sapiens

Features
Gene ID: ENSG00000130287
  
Biological name :NCAN
  
Synonyms : NCAN / neurocan / O14594
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 19211973
Gene end: 19252233
  
Corresponding Affymetrix probe sets: 205143_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000252575
Ensembl peptide - ENSP00000465599
NCBI entrez gene - 1463     See in Manteia.
OMIM - 600826
RefSeq - NM_004386
RefSeq Peptide - NP_004377
swissprot - A0A024R7M3
swissprot - K7EKF8
swissprot - O14594
Ensembl - ENSG00000130287
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU861477.1ENSDARG00000100128Danio rerio
 ncanbENSDARG00000005783Danio rerio
 NCANENSGALG00000036484Gallus gallus
 NcanENSMUSG00000002341Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACAN / aggrecanENSG0000015776634
VCAN / P13611 / versicanENSG0000003842733
BCAN / Q96GW7 / brevicanENSG0000013269225
STAB1 / Q9NY15 / stabilin 1ENSG0000001032717
STAB2 / Q8WWQ8 / stabilin 2ENSG0000013601116
HAPLN3 / Q96S86 / hyaluronan and proteoglycan link protein 3ENSG0000014051111
HAPLN4 / Q86UW8 / hyaluronan and proteoglycan link protein 4ENSG0000018766411
HAPLN2 / Q9GZV7 / hyaluronan and proteoglycan link protein 2ENSG0000013270210
HAPLN1 / P10915 / hyaluronan and proteoglycan link protein 1ENSG0000014568110
P98066 / TNFAIP6 / TNF alpha induced protein 6ENSG000001236105


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR001881  EGF-like calcium-binding domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018378  C-type lectin, conserved site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0030206 chondroitin sulfate biosynthetic process TAS
 biological_processGO:0030207 chondroitin sulfate catabolic process TAS
 biological_processGO:0030208 dermatan sulfate biosynthetic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0005201 extracellular matrix structural constituent IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005540 hyaluronic acid binding IBA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
L1CAM interactions
NCAM1 interactions
Defective B3GALT6 causes EDSP2 and SEMDJL1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex






 

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