ENSMUSG00000002341


Mus musculus

Features
Gene ID: ENSMUSG00000002341
  
Biological name :Ncan
  
Synonyms : Ncan / neurocan
  
Possible biological names infered from orthology : O14594
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 70093085
Gene end: 70120873
  
Corresponding Affymetrix probe sets: 10579165 (MoGene1.0st)   1423604_at (Mouse Genome 430 2.0 Array)   1434679_at (Mouse Genome 430 2.0 Array)   1444020_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002412
NCBI entrez gene - 13004     See in Manteia.
MGI - MGI:104694
RefSeq - NM_007789
RefSeq - XM_006509543
RefSeq Peptide - NP_031815
swissprot - A0A0R4IZX5
Ensembl - ENSMUSG00000002341
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU861477.1ENSDARG00000100128Danio rerio
 ncanbENSDARG00000005783Danio rerio
 NCANENSGALG00000036484Gallus gallus
 NCANENSG00000130287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vcan / versican / P13611*ENSMUSG0000002161432
Acan / Q61282 / Aggrecan core protein / aggrecan*ENSMUSG0000003060730
Bcan / Q61361 / Brevican core protein / Q96GW7* / brevican*ENSMUSG0000000489225
Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*ENSMUSG0000003545915
Stab1 / stabilin 1 / Q9NY15*ENSMUSG0000004228615
Hapln3 / Q80WM5 / Hyaluronan and proteoglycan link protein 3 / Q96S86*ENSMUSG0000003060611
Hapln4 / Q80WM4 / Hyaluronan and proteoglycan link protein 4 / Q86UW8*ENSMUSG0000000759411
Hapln2 / Q9ESM3 / hyaluronan and proteoglycan link protein 2 / Q9GZV7*ENSMUSG0000000489410
Hapln1 / Q9QUP5 / Hyaluronan and proteoglycan link protein 1 / P10915*ENSMUSG0000002161310
O08859 / Tnfaip6 / tumor necrosis factor alpha induced protein 6 / P98066* / TNF alpha induced protein 6*ENSMUSG000000534755


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR001881  EGF-like calcium-binding domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018097  EGF-like calcium-binding, conserved site
 IPR018378  C-type lectin, conserved site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ncantm2Ref/Ncantm2Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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