ENSMUSG00000042286


Mus musculus

Features
Gene ID: ENSMUSG00000042286
  
Biological name :Stab1
  
Synonyms : Stab1 / stabilin 1
  
Possible biological names infered from orthology : Q9NY15
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 31139013
Gene end: 31168641
  
Corresponding Affymetrix probe sets: 10418506 (MoGene1.0st)   1450199_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046199
Ensembl peptide - ENSMUSP00000125239
Ensembl peptide - ENSMUSP00000125542
NCBI entrez gene - 192187     See in Manteia.
MGI - MGI:2178742
RefSeq - NM_138672
RefSeq Peptide - NP_619613
swissprot - G3X973
swissprot - F7CT68
swissprot - F7BK35
Ensembl - ENSMUSG00000042286
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stab1ENSDARG00000076484Danio rerio
 STAB1ENSGALG00000043672Gallus gallus
 STAB1ENSG00000010327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*ENSMUSG0000003545940
Acan / Q61282 / Aggrecan core protein / aggrecan*ENSMUSG000000306079
Vcan / versican / P13611*ENSMUSG000000216149
Ncan / neurocan / O14594*ENSMUSG000000023418
Bcan / Q61361 / Brevican core protein / Q96GW7* / brevican*ENSMUSG000000048926
Hapln3 / Q80WM5 / Hyaluronan and proteoglycan link protein 3 / Q96S86*ENSMUSG000000306063
Hapln4 / Q80WM4 / Hyaluronan and proteoglycan link protein 4 / Q86UW8*ENSMUSG000000075943
Hapln1 / Q9QUP5 / Hyaluronan and proteoglycan link protein 1 / P10915*ENSMUSG000000216132
O08859 / Tnfaip6 / tumor necrosis factor alpha induced protein 6 / P98066* / TNF alpha induced protein 6*ENSMUSG000000534752
Hapln2 / Q9ESM3 / hyaluronan and proteoglycan link protein 2 / Q9GZV7*ENSMUSG000000048942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR000782  FAS1 domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR024731  EGF domain
 IPR036378  FAS1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0042742 defense response to bacterium IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA


Pathways (from Reactome)
Pathway description
Scavenging by Class H Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca)Egan/Gt(ROSA)26Sor+,Tg(MMTV-cre)#Tfln/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0011009 increased circulating glutamate dehydrogenase level "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018593 Sparc / P07214 / secreted acidic cysteine rich glycoprotein / P09486* / secreted protein acidic and cysteine rich*  / reaction / complex






 

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