ENSMUSG00000018593


Mus musculus

Features
Gene ID: ENSMUSG00000018593
  
Biological name :Sparc
  
Synonyms : P07214 / secreted acidic cysteine rich glycoprotein / Sparc
  
Possible biological names infered from orthology : P09486 / secreted protein acidic and cysteine rich
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 55394500
Gene end: 55423183
  
Corresponding Affymetrix probe sets: 10386058 (MoGene1.0st)   1416589_at (Mouse Genome 430 2.0 Array)   1448392_at (Mouse Genome 430 2.0 Array)   1458204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104486
Ensembl peptide - ENSMUSP00000149918
Ensembl peptide - ENSMUSP00000018737
Ensembl peptide - ENSMUSP00000151000
Ensembl peptide - ENSMUSP00000119475
Ensembl peptide - ENSMUSP00000149604
NCBI entrez gene - 20692     See in Manteia.
MGI - MGI:98373
RefSeq - NM_001290817
RefSeq - NM_009242
RefSeq Peptide - NP_001277746
RefSeq Peptide - NP_033268
swissprot - A0A1L1SSH9
swissprot - Q5NCU5
swissprot - P07214
swissprot - Q5NCU3
swissprot - Q5NCU4
Ensembl - ENSMUSG00000018593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sparcENSDARG00000019353Danio rerio
 SPARCENSGALG00000004184Gallus gallus
 SPARCENSG00000113140Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70663 / Sparcl1 / SPARC-like protein 1 / Q14515* / SPARC like 1*ENSMUSG0000002930951


Protein motifs (from Interpro)
Interpro ID Name
 IPR001999  Osteonectin-like, conserved site
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR011992  EF-hand domain pair
 IPR015369  Follistatin/Osteonectin EGF domain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR019577  SPARC/Testican, calcium-binding domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033591 response to L-ascorbic acid IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0060348 bone development IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0031091 platelet alpha granule ISO
 cellular_componentGO:0031092 platelet alpha granule membrane ISO
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ECM proteoglycans
Scavenging by Class H Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001542 abnormal bone strength "change in the ability of bone to endure the application of force without yielding or breaking" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smstm1a(EUCOMM)Wtsi/Y
Genetic Background: B6JTyr;B6N-Smstm1a(EUCOMM)Wtsi/Wtsi

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0006201 vitreous body inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010096 abnormal incisor color "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Sparctm1a(EUCOMM)Wtsi/Wtsi

 MP:0010251 subcapsular cataracts "a lens opacity localized beneath the anterior or posterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Htttm1Mem/Htttm1Mem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010253 posterior subcapsular cataracts "a lens opacity localized beneath the posterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010255 cortical cataracts "a lens opacity, frequently punctate, affecting the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042286 Stab1 / stabilin 1 / Q9NY15*  / reaction / complex






 

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