ENSDARG00000019353


Danio rerio

Features
Gene ID: ENSDARG00000019353
  
Biological name :sparc
  
Synonyms : secreted protein, acidic, cysteine-rich (osteonectin) / sparc
  
Possible biological names infered from orthology : P07214 / P09486 / secreted acidic cysteine rich glycoprotein / secreted protein acidic and cysteine rich
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 25937948
Gene end: 25956860
  
Corresponding Affymetrix probe sets: Dr.18282.3.S1_at (Zebrafish Array)   NM_001001942_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000118359
Ensembl peptide - ENSDARP00000156380
Ensembl peptide - ENSDARP00000123354
Ensembl peptide - ENSDARP00000120684
Ensembl peptide - ENSDARP00000039659
NCBI entrez gene - 321357     See in Manteia.
RefSeq - NM_001001942
RefSeq Peptide - NP_001001942
swissprot - E9QJA9
swissprot - E9QCC2
swissprot - E9QJC0
swissprot - Q6PVV8
ZFIN ID - ZDB-GENE-030131-9
Ensembl - ENSDARG00000019353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPARCENSGALG00000004184Gallus gallus
 SPARCENSG00000113140Homo sapiens
 SparcENSMUSG00000018593Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sparcl1 / SPARC-like 1 / P70663* / Q14515* / SPARC-like protein 1 *ENSDARG0000007498957


Protein motifs (from Interpro)
Interpro ID Name
 IPR001999  Osteonectin-like, conserved site
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR011992  EF-hand domain pair
 IPR015369  Follistatin/Osteonectin EGF domain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR019577  SPARC/Testican, calcium-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0032474 otolith morphogenesis IMP
 biological_processGO:0048752 semicircular canal morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060037 pharyngeal system development IMP
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ECM proteoglycans
Scavenging by Class H Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm decreased amount , abnormal
intermediate cell mass of mesoderm cell proliferation increased occurrence , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
Show

 ZFA:0000094 blood island blood island decreased amount , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000168 anterior macula anterior macula position , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
Show

 ZFA:0000220 lateral semicircular canal lateral semicircular canal aplastic , abnormal
Show

 ZFA:0000225 lateral crista primordium lateral crista primordium aplastic , abnormal
Show

 ZFA:0000257 pectoral fin cartilage pectoral fin cartilage morphology , abnormal
Show

 ZFA:0000262 posterior semicircular canal posterior semicircular canal aplastic , abnormal
Show

 ZFA:0000314 anterior semicircular canal anterior semicircular canal aplastic , abnormal
Show

 ZFA:0000558 posterior macula posterior macula position , abnormal
Show

 ZFA:0000559 otolith organ otolith organ lacks parts or has fewer parts of type otolith , abnormal
otolith organ has extra parts of type otolith , abnormal
Show

 ZFA:0001058 caudal fin caudal fin kinked , abnormal
Show

 ZFA:0001094 whole organism whole organism curved dorsal , abnormal
whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001097 immature posterior macula immature posterior macula aplastic , abnormal
Show

 ZFA:0001114 head head apoptotic , abnormal
Show

 ZFA:0001115 trunk trunk apoptotic process increased occurrence , abnormal
Show

 ZFA:0001138 vestibuloauditory system vestibuloauditory system functionality , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
pectoral fin kinked , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage aplastic , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased size , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage aplastic , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
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 ZFA:0001461 chondrocranium cartilage chondrocranium cartilage decreased size , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage aplastic , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
otolith composition , abnormal
otolith fused with otolith , abnormal
otolith mislocalised , abnormal
Show

 ZFA:0009044 blood cell blood cell decreased amount , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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