ENSMUSG00000053475


Mus musculus

Features
Gene ID: ENSMUSG00000053475
  
Biological name :Tnfaip6
  
Synonyms : O08859 / Tnfaip6 / tumor necrosis factor alpha induced protein 6
  
Possible biological names infered from orthology : P98066 / TNF alpha induced protein 6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.1
Gene start: 52038009
Gene end: 52056686
  
Corresponding Affymetrix probe sets: 10472050 (MoGene1.0st)   1418424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069231
NCBI entrez gene - 21930     See in Manteia.
MGI - MGI:1195266
RefSeq - NM_009398
RefSeq Peptide - NP_033424
swissprot - O08859
swissprot - Q3USX6
Ensembl - ENSMUSG00000053475
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaip6ENSDARG00000093440Danio rerio
 TNFAIP6ENSGALG00000012481Gallus gallus
 P98066ENSG00000123610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vcan / versican / P13611*ENSMUSG0000002161427
Ncan / neurocan / O14594*ENSMUSG0000000234125
Acan / Q61282 / Aggrecan core protein / aggrecan*ENSMUSG0000003060725
Bcan / Q61361 / Brevican core protein / Q96GW7* / brevican*ENSMUSG0000000489224
Hapln2 / Q9ESM3 / hyaluronan and proteoglycan link protein 2 / Q9GZV7*ENSMUSG0000000489421
Hapln4 / Q80WM4 / Hyaluronan and proteoglycan link protein 4 / Q86UW8*ENSMUSG0000000759420
Hapln3 / Q80WM5 / Hyaluronan and proteoglycan link protein 3 / Q96S86*ENSMUSG0000003060619
Hapln1 / Q9QUP5 / Hyaluronan and proteoglycan link protein 1 / P10915*ENSMUSG0000002161318
Stab1 / stabilin 1 / Q9NY15*ENSMUSG0000004228616
Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*ENSMUSG0000003545916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR000859  CUB domain
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: C57BL/6-Rag2tm1.1Cgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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