ENSMUSG00000035459


Mus musculus

Features
Gene ID: ENSMUSG00000035459
  
Biological name :Stab2
  
Synonyms : Q8R4U0 / Stab2 / Stabilin-2 Short form stabilin-2
  
Possible biological names infered from orthology : Q8WWQ8 / stabilin 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 86841198
Gene end: 87008025
  
Corresponding Affymetrix probe sets: 10371506 (MoGene1.0st)   1419423_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048309
Ensembl peptide - ENSMUSP00000151465
NCBI entrez gene - 192188     See in Manteia.
MGI - MGI:2178743
RefSeq - NM_138673
RefSeq Peptide - NP_619614
swissprot - E5RKF9
swissprot - A0A1W2P6Y4
swissprot - Q8R4U0
Ensembl - ENSMUSG00000035459
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stab2ENSDARG00000045748Danio rerio
 STAB2ENSG00000136011Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stab1 / stabilin 1 / Q9NY15*ENSMUSG0000004228640
Acan / Q61282 / Aggrecan core protein / aggrecan*ENSMUSG000000306079
Vcan / versican / P13611*ENSMUSG000000216149
Ncan / neurocan / O14594*ENSMUSG000000023418
Bcan / Q61361 / Brevican core protein / Q96GW7* / brevican*ENSMUSG000000048926
Hapln4 / Q80WM4 / Hyaluronan and proteoglycan link protein 4 / Q86UW8*ENSMUSG000000075943
Hapln1 / Q9QUP5 / Hyaluronan and proteoglycan link protein 1 / P10915*ENSMUSG000000216133
O08859 / Tnfaip6 / tumor necrosis factor alpha induced protein 6 / P98066* / TNF alpha induced protein 6*ENSMUSG000000534752
Hapln3 / Q80WM5 / Hyaluronan and proteoglycan link protein 3 / Q96S86*ENSMUSG000000306062
Hapln2 / Q9ESM3 / hyaluronan and proteoglycan link protein 2 / Q9GZV7*ENSMUSG000000048942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR000782  FAS1 domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR024731  EGF domain
 IPR036378  FAS1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis ISS
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity ISO
 molecular_functionGO:0005044 scavenger receptor activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding ISO


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation
Scavenging by Class H Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

Allelic Composition: Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: B6.129S2-Stab2tm1.1Cger

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0011009 increased circulating glutamate dehydrogenase level "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic Background: C.129S2-Stab1tm1.1Cger

Allelic Composition: Stab1tm1.1Cger/Stab1tm1.1Cger,Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic Background: C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014077 Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*  / reaction / complex
 ENSMUSG00000028854 Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*  / reaction / complex
 ENSMUSG00000010047 Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*  / reaction / complex






 

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