ENSG00000136011


Homo sapiens

Features
Gene ID: ENSG00000136011
  
Biological name :STAB2
  
Synonyms : Q8WWQ8 / STAB2 / stabilin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.3
Gene start: 103587273
Gene end: 103766727
  
Corresponding Affymetrix probe sets: 220114_s_at (Human Genome U133 Plus 2.0 Array)   237567_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373539
Ensembl peptide - ENSP00000446629
Ensembl peptide - ENSP00000449282
NCBI entrez gene - 55576     See in Manteia.
OMIM - 608561
RefSeq - XM_017019585
RefSeq - XM_011538537
RefSeq - XM_011538538
RefSeq - XM_011538539
RefSeq - XM_011538541
RefSeq - NM_017564
RefSeq Peptide - NP_060034
swissprot - H0YIF3
swissprot - H0YHA5
swissprot - Q8WWQ8
Ensembl - ENSG00000136011
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stab2ENSDARG00000045748Danio rerio
 Stab2ENSMUSG00000035459Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAB1 / Q9NY15 / stabilin 1ENSG0000001032741
ACAN / aggrecanENSG0000015776611
VCAN / P13611 / versicanENSG0000003842710
NCAN / O14594 / neurocanENSG000001302878
BCAN / Q96GW7 / brevicanENSG000001326926
HAPLN3 / Q96S86 / hyaluronan and proteoglycan link protein 3ENSG000001405113
HAPLN4 / Q86UW8 / hyaluronan and proteoglycan link protein 4ENSG000001876643
P98066 / TNFAIP6 / TNF alpha induced protein 6ENSG000001236102
HAPLN1 / P10915 / hyaluronan and proteoglycan link protein 1ENSG000001456812
HAPLN2 / Q9GZV7 / hyaluronan and proteoglycan link protein 2ENSG000001327022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR000782  FAS1 domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR024731  EGF domain
 IPR036378  FAS1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis NAS
 biological_processGO:0006897 endocytosis ISS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0030214 hyaluronan catabolic process TAS
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IDA
 molecular_functionGO:0005044 scavenger receptor activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005540 hyaluronic acid binding ISS
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity NAS
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation
Scavenging by Class H Receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090020 P19634 / SLC9A1 / solute carrier family 9 member A1  / complex / reaction
 ENSG00000187446 CHP1 / Q99653 / calcineurin like EF-hand protein 1  / reaction / complex
 ENSG00000068001 HYAL2 / Q12891 / hyaluronoglucosaminidase 2  / reaction / complex






 

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