ENSG00000068001


Homo sapiens

Features
Gene ID: ENSG00000068001
  
Biological name :HYAL2
  
Synonyms : HYAL2 / hyaluronoglucosaminidase 2 / Q12891
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 50317790
Gene end: 50322906
  
Corresponding Affymetrix probe sets: 206855_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398714
Ensembl peptide - ENSP00000399677
Ensembl peptide - ENSP00000414656
Ensembl peptide - ENSP00000409642
Ensembl peptide - ENSP00000406657
Ensembl peptide - ENSP00000405855
Ensembl peptide - ENSP00000401853
Ensembl peptide - ENSP00000350387
Ensembl peptide - ENSP00000378571
NCBI entrez gene - 8692     See in Manteia.
OMIM - 603551
RefSeq - XM_005265525
RefSeq - NM_003773
RefSeq - NM_033158
RefSeq - XM_005265524
RefSeq Peptide - NP_149348
RefSeq Peptide - NP_003764
swissprot - C9K016
swissprot - C9JSI7
swissprot - C9JSD1
swissprot - C9J700
swissprot - C9JBF5
swissprot - Q12891
Ensembl - ENSG00000068001
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyal2aENSDARG00000059931Danio rerio
 hyal2bENSDARG00000062997Danio rerio
 HYAL2ENSGALG00000002138Gallus gallus
 Hyal2ENSMUSG00000010047Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HYAL4 / Q2M3T9 / hyaluronoglucosaminidase 4ENSG0000010630238
HYAL3 / O43820 / hyaluronoglucosaminidase 3ENSG0000018679237
HYAL1 / Q12794 / hyaluronoglucosaminidase 1ENSG0000011437837
SPAM1 / P38567 / sperm adhesion molecule 1ENSG0000010630435


Protein motifs (from Interpro)
Interpro ID Name
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IDA
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006027 glycosaminoglycan catabolic process IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IDA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane IDA
 biological_processGO:0019087 transformation of host cell by virus ISS
 biological_processGO:0030214 hyaluronan catabolic process TAS
 biological_processGO:0030308 negative regulation of cell growth IDA
 biological_processGO:0035810 positive regulation of urine volume ISS
 biological_processGO:0042117 monocyte activation IDA
 biological_processGO:0042307 positive regulation of protein import into nucleus ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046677 response to antibiotic IEP
 biological_processGO:0046718 viral entry into host cell ISS
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0051216 cartilage development IEP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IDA
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IDA
 biological_processGO:0070295 renal water absorption ISS
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071493 cellular response to UV-B IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0000139 Golgi membrane ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum NAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0046658 anchored component of plasma membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISS
 molecular_functionGO:0001618 virus receptor activity IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005540 hyaluronic acid binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030294 receptor signaling protein tyrosine kinase inhibitor activity IDA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0033906 hyaluronoglucuronidase activity IDA
 molecular_functionGO:0050431 transforming growth factor beta binding ISS


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090020 P19634 / SLC9A1 / solute carrier family 9 member A1  / reaction / complex
 ENSG00000187446 CHP1 / Q99653 / calcineurin like EF-hand protein 1  / complex / reaction
 ENSG00000072571 HMMR / O75330 / hyaluronan mediated motility receptor  / reaction / complex
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / complex / reaction
 ENSG00000133800 LYVE1 / Q9Y5Y7 / lymphatic vessel endothelial hyaluronan receptor 1  / complex / reaction
 ENSG00000136011 STAB2 / Q8WWQ8 / stabilin 2  / reaction / complex






 

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