ENSGALG00000002138


Gallus gallus

Features
Gene ID: ENSGALG00000002138
  
Biological name :HYAL2
  
Synonyms : HYAL2 / hyaluronoglucosaminidase 2
  
Possible biological names infered from orthology : Hyaluronidase-2 / O35632 / Q12891
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 1447839
Gene end: 1450278
  
Corresponding Affymetrix probe sets: GgaAffx.1417.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003336
NCBI entrez gene - 415908     See in Manteia.
RefSeq - XM_414258
swissprot - H9KZ20
Ensembl - ENSGALG00000002138
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyal2aENSDARG00000059931Danio rerio
 hyal2bENSDARG00000062997Danio rerio
 HYAL2ENSG00000068001Homo sapiens
 Hyal2ENSMUSG00000010047Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HYAL6 / hyaluronoglucosaminidase 6*ENSGALG0000000877644
SPAM1 / sperm adhesion molecule 1 / Hyal5* / P38567* / P48794* / Q812F3* / Hyaluronidase-5 *ENSGALG0000000876140
HYAL3 / hyaluronoglucosaminidase 3 / O43820* / Q8VEI3* / Hyaluronidase-3 *ENSGALG0000002900038
HYAL1 / hyaluronoglucosaminidase 1 / Q12794* / Q91ZJ9* / Mus musculus hyaluronoglucosaminidase 1 (Hyal1), transcript variant 2, mRNA.*ENSGALG0000000078538


Protein motifs (from Interpro)
Interpro ID Name
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006027 glycosaminoglycan catabolic process IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IEA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane IEA
 biological_processGO:0019087 transformation of host cell by virus IEA
 biological_processGO:0030214 hyaluronan catabolic process IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0042117 monocyte activation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060586 multicellular organismal iron ion homeostasis IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030294 receptor signaling protein tyrosine kinase inhibitor activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0033906 hyaluronoglucuronidase activity IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005643 LYVE1 / lymphatic vessel endothelial hyaluronan receptor 1 / Q8BHC0* / Q9Y5Y7* / Lymphatic vessel endothelial hyaluronic acid receptor 1 *  / complex / reaction
 ENSGALG00000008569 CHP1 / Q5ZM44 / Calcineurin B homologous protein 1 / P61022* / Q99653* / calcineurin like EF-hand protein 1*  / complex / reaction
 ENSGALG00000042009 HMMR / hyaluronan mediated motility receptor / O75330* / Q00547*  / reaction / complex
 ENSGALG00000039080 CD44 / CD44 molecule (Indian blood group) / P16070*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr