ENSG00000026508


Homo sapiens

Features
Gene ID: ENSG00000026508
  
Biological name :CD44
  
Synonyms : CD44 / CD44 molecule (Indian blood group) / P16070
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p13
Gene start: 35138870
Gene end: 35232402
  
Corresponding Affymetrix probe sets: 1557905_s_at (Human Genome U133 Plus 2.0 Array)   204489_s_at (Human Genome U133 Plus 2.0 Array)   204490_s_at (Human Genome U133 Plus 2.0 Array)   209835_x_at (Human Genome U133 Plus 2.0 Array)   210916_s_at (Human Genome U133 Plus 2.0 Array)   212014_x_at (Human Genome U133 Plus 2.0 Array)   212063_at (Human Genome U133 Plus 2.0 Array)   216056_at (Human Genome U133 Plus 2.0 Array)   217523_at (Human Genome U133 Plus 2.0 Array)   229221_at (Human Genome U133 Plus 2.0 Array)   234411_x_at (Human Genome U133 Plus 2.0 Array)   234418_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436623
Ensembl peptide - ENSP00000436549
Ensembl peptide - ENSP00000436980
Ensembl peptide - ENSP00000492449
Ensembl peptide - ENSP00000263398
Ensembl peptide - ENSP00000278385
Ensembl peptide - ENSP00000278386
Ensembl peptide - ENSP00000279452
Ensembl peptide - ENSP00000309732
Ensembl peptide - ENSP00000389830
Ensembl peptide - ENSP00000392331
Ensembl peptide - ENSP00000395953
Ensembl peptide - ENSP00000398099
Ensembl peptide - ENSP00000398632
Ensembl peptide - ENSP00000404447
Ensembl peptide - ENSP00000431860
Ensembl peptide - ENSP00000432405
Ensembl peptide - ENSP00000432704
Ensembl peptide - ENSP00000432718
Ensembl peptide - ENSP00000433189
Ensembl peptide - ENSP00000434418
Ensembl peptide - ENSP00000434465
Ensembl peptide - ENSP00000434530
Ensembl peptide - ENSP00000434920
Ensembl peptide - ENSP00000435321
Ensembl peptide - ENSP00000435377
Ensembl peptide - ENSP00000436451
NCBI entrez gene - 960     See in Manteia.
OMIM - 107269
RefSeq - XM_017018585
RefSeq - NM_000610
RefSeq - NM_001001389
RefSeq - NM_001001390
RefSeq - NM_001001391
RefSeq - NM_001001392
RefSeq - NM_001202555
RefSeq - NM_001202556
RefSeq - NM_001202557
RefSeq - XM_005253231
RefSeq - XM_005253232
RefSeq - XM_005253233
RefSeq - XM_005253234
RefSeq - XM_005253235
RefSeq - XM_005253238
RefSeq - XM_005253239
RefSeq - XM_005253240
RefSeq - XM_006718388
RefSeq - XM_011520482
RefSeq - XM_011520483
RefSeq - XM_011520484
RefSeq - XM_011520485
RefSeq - XM_011520486
RefSeq - XM_011520488
RefSeq - XM_017018583
RefSeq - XM_017018584
RefSeq Peptide - NP_001001390
RefSeq Peptide - NP_001001391
RefSeq Peptide - NP_001001392
RefSeq Peptide - NP_001189484
RefSeq Peptide - NP_001189485
RefSeq Peptide - NP_001189486
RefSeq Peptide - NP_000601
RefSeq Peptide - NP_001001389
swissprot - H0YD90
swissprot - H0YDV8
swissprot - H0YDW7
swissprot - H0YDX6
swissprot - H0YE40
swissprot - H0YEA1
swissprot - H0YES0
swissprot - H0YEU1
swissprot - H0YEV3
swissprot - H0YF08
swissprot - J3KN83
swissprot - P16070
swissprot - A0A1W2PR55
swissprot - Q86UZ1
swissprot - E9PKC6
swissprot - H0Y2P0
swissprot - H0Y5E4
swissprot - H0YCL4
swissprot - H0YCV9
swissprot - H0YD13
swissprot - H0YD17
Ensembl - ENSG00000026508
  
Related genetic diseases (OMIM): 609027 - [Blood group, Indian system], 609027
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd44aENSDARG00000087863Danio rerio
 cd44bENSDARG00000089892Danio rerio
 CD44ENSGALG00000039080Gallus gallus
 Cd44ENSMUSG00000005087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LYVE1 / Q9Y5Y7 / lymphatic vessel endothelial hyaluronan receptor 1ENSG000001338009


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR001231  CD44 antigen
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion NAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030214 hyaluronan catabolic process TAS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051216 cartilage development IEP
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070487 monocyte aggregation IMP
 biological_processGO:0098609 cell-cell adhesion NAS
 biological_processGO:1900625 positive regulation of monocyte aggregation IMP
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:2000392 regulation of lamellipodium morphogenesis IMP
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031258 lamellipodium membrane IDA
 cellular_componentGO:0035692 macrophage migration inhibitory factor receptor complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004896 cytokine receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding NAS
 molecular_functionGO:0005540 hyaluronic acid binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110876 Q14242 / SELPLG / selectin P ligand  / complex / reaction
 ENSG00000090863 GLG1 / Q92896 / golgi glycoprotein 1  / reaction / complex
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / complex / reaction
 ENSG00000100985 MMP9 / P14780 / matrix metallopeptidase 9  / reaction / complex
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / complex / reaction
 ENSG00000118785 SPP1 / P10451 / secreted phosphoprotein 1  / complex / reaction
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / complex / reaction
 ENSG00000197471 SPN / P16150 / sialophorin  / complex / reaction
 ENSG00000090020 P19634 / SLC9A1 / solute carrier family 9 member A1  / complex / reaction
 ENSG00000187446 CHP1 / Q99653 / calcineurin like EF-hand protein 1  / complex / reaction
 ENSG00000007908 SELE / P16581 / selectin E  / complex / reaction
 ENSG00000068001 HYAL2 / Q12891 / hyaluronoglucosaminidase 2  / complex / reaction






 

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