ENSMUSG00000005087


Mus musculus

Features
Gene ID: ENSMUSG00000005087
  
Biological name :Cd44
  
Synonyms : Cd44 / CD44 molecule (Indian blood group)
  
Possible biological names infered from orthology : P16070
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 102811141
Gene end: 102901665
  
Corresponding Affymetrix probe sets: 10485405 (MoGene1.0st)   1423760_at (Mouse Genome 430 2.0 Array)   1434376_at (Mouse Genome 430 2.0 Array)   1443265_at (Mouse Genome 430 2.0 Array)   1452483_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097265
Ensembl peptide - ENSMUSP00000062330
Ensembl peptide - ENSMUSP00000106821
Ensembl peptide - ENSMUSP00000106829
Ensembl peptide - ENSMUSP00000106825
Ensembl peptide - ENSMUSP00000106823
Ensembl peptide - ENSMUSP00000106822
Ensembl peptide - ENSMUSP00000005218
NCBI entrez gene - 12505     See in Manteia.
MGI - MGI:88338
RefSeq - XM_006498649
RefSeq - NM_001039150
RefSeq - NM_001039151
RefSeq - NM_001177785
RefSeq - NM_001177786
RefSeq - NM_001177787
RefSeq - NM_009851
RefSeq - XM_006498645
RefSeq - XM_006498646
RefSeq - XM_006498647
RefSeq - XM_006498648
RefSeq Peptide - NP_001034240
RefSeq Peptide - NP_001171257
RefSeq Peptide - NP_001171258
RefSeq Peptide - NP_033981
RefSeq Peptide - NP_001171256
RefSeq Peptide - NP_001034239
swissprot - Q3U8S1
swissprot - A2APM1
swissprot - Q80X37
swissprot - E9QKM8
swissprot - A2APM5
swissprot - A2APM4
swissprot - A2APM3
swissprot - A2APM2
Ensembl - ENSMUSG00000005087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd44aENSDARG00000087863Danio rerio
 cd44bENSDARG00000089892Danio rerio
 CD44ENSGALG00000039080Gallus gallus
 CD44ENSG00000026508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lyve1 / Q8BHC0 / Lymphatic vessel endothelial hyaluronic acid receptor 1 / Q9Y5Y7* / lymphatic vessel endothelial hyaluronan receptor 1*ENSMUSG000000307879


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR001231  CD44 antigen
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030214 hyaluronan catabolic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0044319 wound healing, spreading of cells IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070487 monocyte aggregation IEA
 biological_processGO:1900625 positive regulation of monocyte aggregation IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:2000392 regulation of lamellipodium morphogenesis IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0035692 macrophage migration inhibitory factor receptor complex IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005540 hyaluronic acid binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Hyaluronan uptake and degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000362 reduced histamine storage "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adora2btm1.1Msit/Adora2btm1.1Msit
Genetic Background: either: (involves: C57BL/6) or (involves: C57BL/6 * CD-1 * ICR)

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu,Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Grid2tm1Mim/Grid2tm1Mim
Genetic Background: B6.Cg-Grid2tm1Mim

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Cd44tm1Mak Tg(MMTV-PyVT)634Mul

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm5.1Suss/Nkx2-2tm5.1Suss,Tg(Pdx1-cre)6Tuv/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm1Stpa
Genetic Background: involves: C57BL/6J * C57BL/6JIco

Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

Allelic Composition: Cd44tm1Mak/Cd44+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: B6.129(Cg)-Cd44tm1.1Ugu

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: SJL.129(Cg)-Cd44tm1.1Ugu

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Amhr2tm3(cre)Bhr/Amhr2+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Itgaltm1Mak/Itgaltm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak Itgaltm1Mak

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: SJL.129(Cg)-Cd44tm1.1Ugu

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxi1tm1Sven/Foxi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cd44tm1.1Ugu/Cd44tm1.1Ugu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S2-Serpine1tm1Mlg/J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdctm1Gcl/Prkdctm1Gcl
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008162 increased diameter of tibia "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0008591 increased circulating interleukin-1 level "increase in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0008651 increased interleukin-1 secretion "increase in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens" [MESH:D12.644.276.374.465.501]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: involves: C57BL/6 * CBA/CaGnLe

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008800 increased small intestinal crypt cell apoptosis "increase in the number of small intestinal crypt cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnftm2Gkl/Tnf+
Genetic Background: B6.129S-Tnftm2Gkl/Jarn

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
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Allelic Composition: Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu/Evx2/Hoxd13tm5(Hoxd11/lacZ)Ddu
Genetic Background: involves: 129S2/SvPas

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0010677 decreased activation-induced cell death of T cells "decreased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors" [PMID:12752672]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: B6.129P2-Cd44tm1Mak

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Cd44tm1Stpa/Cd44tm1Stpa
Genetic Background: involves: C57BL/6J * C57BL/6JIco

Allelic Composition: ApcMin/Apc+,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: C57BL/6J

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Gab1tm1Wbm/Gab1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg,Tg(TNF)197Gkl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Mettm1Cbm/Met+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Gab1tm1Wbm/Gab1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Hgftm1Kita/Hgf+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Cd44tm1Mak/Cd44tm1Mak,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: Slc6a4tm1.1Rbl/Slc6a4tm1.1Rbl
Genetic Background: 129S6/SvEvTac-Slc6a4tm1.1Rbl

Allelic Composition: ApcMin/Apc+,Cd44tm2Stpa/Cd44tm2Stpa
Genetic Background: involves: C57BL/6J

Allelic Composition: ApcMin/Apc+,Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: C57BL/6J

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cd44tm2Kmz/Cd44tm2Kmz,Selltm2Hyn/Selltm2Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c * DBA/1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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