ENSMUSG00000030787


Mus musculus

Features
Gene ID: ENSMUSG00000030787
  
Biological name :Lyve1
  
Synonyms : Lymphatic vessel endothelial hyaluronic acid receptor 1 / Lyve1 / Q8BHC0
  
Possible biological names infered from orthology : lymphatic vessel endothelial hyaluronan receptor 1 / Q9Y5Y7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 110850607
Gene end: 110863239
  
Corresponding Affymetrix probe sets: 10566934 (MoGene1.0st)   1429379_at (Mouse Genome 430 2.0 Array)   1453128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033050
NCBI entrez gene - 114332     See in Manteia.
MGI - MGI:2136348
RefSeq - NM_053247
RefSeq Peptide - NP_444477
swissprot - Q8BHC0
Ensembl - ENSMUSG00000030787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lyve1bENSDARG00000062483Danio rerio
 LYVE1ENSGALG00000005643Gallus gallus
 LYVE1ENSG00000133800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd44 / CD44 molecule (Indian blood group) / P16070*ENSMUSG0000000508722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000538  Link domain
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006027 glycosaminoglycan catabolic process IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005540 hyaluronic acid binding IDA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
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Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
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Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014077 Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*  / reaction / complex
 ENSMUSG00000028854 Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*  / reaction / complex
 ENSMUSG00000010047 Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*  / complex / reaction






 

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