ENSMUSG00000014077


Mus musculus

Features
Gene ID: ENSMUSG00000014077
  
Biological name :Chp1
  
Synonyms : Calcineurin B homologous protein 1 / Chp1 / P61022
  
Possible biological names infered from orthology : calcineurin like EF-hand protein 1 / Q99653
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119547697
Gene end: 119587027
  
Corresponding Affymetrix probe sets: 10474977 (MoGene1.0st)   1420809_a_at (Mouse Genome 430 2.0 Array)   1420810_at (Mouse Genome 430 2.0 Array)   1450007_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014221
Ensembl peptide - ENSMUSP00000122946
Ensembl peptide - ENSMUSP00000114013
NCBI entrez gene - 56398     See in Manteia.
MGI - MGI:1927185
RefSeq - NM_019769
RefSeq Peptide - NP_062743
swissprot - B0R092
swissprot - B0R091
swissprot - P61022
Ensembl - ENSMUSG00000014077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chp1ENSDARG00000052859Danio rerio
 CHP1ENSGALG00000008569Gallus gallus
 CHP1ENSG00000187446Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chp2 / Q9D869 / Calcineurin B homologous protein 2 / O43745* / calcineurin like EF-hand protein 2*ENSMUSG0000003086559
Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*ENSMUSG0000003395335
Tesc / Q9JKL5 / tescalcin / Q96BS2*ENSMUSG0000002935933
Ppp3r2 / Q63811 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) / Q96LZ3* / protein phosphatase 3 regulatory subunit B, beta*ENSMUSG0000002831032
Tescl / TESC* / Q96BS2* / tescalcin*ENSMUSG0000005582629


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0022406 membrane docking IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032417 positive regulation of sodium:proton antiporter activity IEA
 biological_processGO:0042308 negative regulation of protein import into nucleus IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051222 positive regulation of protein transport IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051453 regulation of intracellular pH IEA
 biological_processGO:0060050 positive regulation of protein glycosylation IEA
 biological_processGO:0061024 membrane organization IEA
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:0070885 negative regulation of calcineurin-NFAT signaling cascade IEA
 biological_processGO:0071468 cellular response to acidic pH ISS
 biological_processGO:0090314 positive regulation of protein targeting to membrane ISS
 biological_processGO:1901214 regulation of neuron death IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Mecp2tm2.1Meg/Y
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010047 Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*  / complex / reaction
 ENSMUSG00000030787 Lyve1 / Q8BHC0 / Lymphatic vessel endothelial hyaluronic acid receptor 1 / Q9Y5Y7* / lymphatic vessel endothelial hyaluronan receptor 1*  / reaction / complex
 ENSMUSG00000020330 Hmmr / Q00547 / Hyaluronan mediated motility receptor / O75330*  / reaction / complex
 ENSMUSG00000035459 Stab2 / Q8R4U0 / Stabilin-2 Short form stabilin-2 / Q8WWQ8* / stabilin 2*  / reaction / complex
 ENSMUSG00000028854 Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*  / complex






 

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