ENSMUSG00000028310


Mus musculus

Features
Gene ID: ENSMUSG00000028310
  
Biological name :Ppp3r2
  
Synonyms : Ppp3r2 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) / Q63811
  
Possible biological names infered from orthology : protein phosphatase 3 regulatory subunit B, beta / Q96LZ3
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 49678747
Gene end: 49682024
  
Corresponding Affymetrix probe sets: 10512930 (MoGene1.0st)   1437535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029991
NCBI entrez gene - 19059     See in Manteia.
MGI - MGI:107171
RefSeq - NM_001004025
RefSeq Peptide - NP_001004025
swissprot - Q497S1
swissprot - Q63811
Ensembl - ENSMUSG00000028310
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp3r1aENSDARG00000092659Danio rerio
 PPP3R1ENSGALG00000023648Gallus gallus
 PPP3R2ENSG00000188386Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppp3r1 / Q63810 / protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) / P63098* / protein phosphatase 3 regulatory subunit B, alpha*ENSMUSG0000003395377
Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*ENSMUSG0000001407735
Chp2 / Q9D869 / Calcineurin B homologous protein 2 / O43745* / calcineurin like EF-hand protein 2*ENSMUSG0000003086532
Tescl / TESC* / Q96BS2* / tescalcin*ENSMUSG0000005582626
Tesc / Q9JKL5 / tescalcin / Q96BS2*ENSMUSG0000002935925


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007321 sperm displacement TAS
 molecular_functionGO:0004723 calcium-dependent protein serine/threonine phosphatase activity ISS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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