ENSMUSG00000020330


Mus musculus

Features
Gene ID: ENSMUSG00000020330
  
Biological name :Hmmr
  
Synonyms : Hmmr / Hyaluronan mediated motility receptor / Q00547
  
Possible biological names infered from orthology : O75330
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A5
Gene start: 40701395
Gene end: 40733422
  
Corresponding Affymetrix probe sets: 10385248 (MoGene1.0st)   1425815_a_at (Mouse Genome 430 2.0 Array)   1427541_x_at (Mouse Genome 430 2.0 Array)   1429871_at (Mouse Genome 430 2.0 Array)   1450156_a_at (Mouse Genome 430 2.0 Array)   1450157_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020579
NCBI entrez gene - 15366     See in Manteia.
MGI - MGI:104667
RefSeq - XM_006532279
RefSeq - NM_013552
RefSeq - XM_006532276
RefSeq - XM_006532278
RefSeq Peptide - NP_038580
swissprot - Q00547
Ensembl - ENSMUSG00000020330
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmmrENSDARG00000021794Danio rerio
 HMMRENSGALG00000042009Gallus gallus
 HMMRENSG00000072571Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026203  Intracellular hyaluronic acid binding protein
 IPR031787  Hyaluronan mediated motility receptor, N-terminal
 IPR031794  Hyaluronan-mediated motility receptor, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 molecular_functionGO:0005540 hyaluronic acid binding IBA


Pathways (from Reactome)
Pathway description
Hyaluronan uptake and degradation
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0011125 decreased primary ovarian follicle number "fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

 MP:0011129 decreased secondary ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2+
Genetic Background: involves: MEV/2Ty

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014077 Chp1 / P61022 / Calcineurin B homologous protein 1 / Q99653* / calcineurin like EF-hand protein 1*  / reaction / complex
 ENSMUSG00000010047 Hyal2 / O35632 / Hyaluronidase-2 / Q12891* / hyaluronoglucosaminidase 2*  / reaction / complex
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / reaction / complex
 ENSMUSG00000028854 Q61165 / Slc9a1 / solute carrier family 9 (sodium/hydrogen exchanger), member 1 / P19634* / solute carrier family 9 member A1*  / complex / reaction
 ENSMUSG00000027469 Tpx2 / A2APB8 / Targeting protein for Xklp2 / Q9ULW0* / TPX2, microtubule nucleation factor*  / complex / reaction






 

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