ENSMUSG00000027469


Mus musculus

Features
Gene ID: ENSMUSG00000027469
  
Biological name :Tpx2
  
Synonyms : A2APB8 / Targeting protein for Xklp2 / Tpx2
  
Possible biological names infered from orthology : Q9ULW0 / TPX2, microtubule nucleation factor
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 152847964
Gene end: 152895321
  
Corresponding Affymetrix probe sets: 10477187 (MoGene1.0st)   1428104_at (Mouse Genome 430 2.0 Array)   1428105_at (Mouse Genome 430 2.0 Array)   1447518_at (Mouse Genome 430 2.0 Array)   1447519_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028969
Ensembl peptide - ENSMUSP00000105441
Ensembl peptide - ENSMUSP00000128888
Ensembl peptide - ENSMUSP00000136457
NCBI entrez gene - 72119     See in Manteia.
MGI - MGI:1919369
RefSeq - XM_006500215
RefSeq - NM_001141975
RefSeq - NM_001141976
RefSeq - NM_001141977
RefSeq - NM_001141978
RefSeq - NM_028109
RefSeq - XM_006500213
RefSeq - XM_006500214
RefSeq Peptide - NP_001135449
RefSeq Peptide - NP_001135450
RefSeq Peptide - NP_082385
RefSeq Peptide - NP_001135447
RefSeq Peptide - NP_001135448
swissprot - A2APB8
Ensembl - ENSMUSG00000027469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpx2ENSDARG00000078654Danio rerio
 TPX2ENSGALG00000006267Gallus gallus
 TPX2ENSG00000088325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009675  TPX2
 IPR015128  Aurora-A binding
 IPR027329  TPX2, C-terminal
 IPR027330  TPX2 central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032147 activation of protein kinase activity ISO
 biological_processGO:0051225 spindle assembly ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060236 regulation of mitotic spindle organization IMP
 biological_processGO:0090307 mitotic spindle assembly ISS
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005818 aster ISO
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0043203 axon hillock IDA
 cellular_componentGO:0045171 intercellular bridge ISO
 cellular_componentGO:0072686 mitotic spindle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0061676 importin-alpha family protein binding ISO


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tpx2Gt(D028B03)1.2Wrst/Tpx2Gt(D028B03)1.2Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tpx2Gt(D028B03)1.2Wrst/Tpx2Gt(D028B03)1.2Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tpx2Gt(D028B03)1.2Wrst/Tpx2Gt(D028B03)1.2Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008371 pituitary intermediate lobe hyperplasia "overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Tpx2Gt(D028B03)1.1Wrst/Tpx2Gt(D028B03)1.1Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Nprl3tm1.1Drhi/Nprl3tm1.1Drhi
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020330 Hmmr / Q00547 / Hyaluronan mediated motility receptor / O75330*  / reaction / complex
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / reaction / complex






 

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