ENSG00000088325


Homo sapiens

Features
Gene ID: ENSG00000088325
  
Biological name :TPX2
  
Synonyms : Q9ULW0 / TPX2 / TPX2, microtubule nucleation factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.21
Gene start: 31739271
Gene end: 31801805
  
Corresponding Affymetrix probe sets: 210052_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300403
Ensembl peptide - ENSP00000341145
NCBI entrez gene - 22974     See in Manteia.
OMIM - 605917
RefSeq - XM_011528700
RefSeq - NM_012112
RefSeq - XM_011528697
RefSeq - XM_011528699
RefSeq Peptide - NP_036244
swissprot - Q643R0
swissprot - Q9ULW0
Ensembl - ENSG00000088325
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpx2ENSDARG00000078654Danio rerio
 TPX2ENSGALG00000006267Gallus gallus
 Tpx2ENSMUSG00000027469Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009675  TPX2
 IPR015128  Aurora-A binding
 IPR027329  TPX2, C-terminal
 IPR027330  TPX2 central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060236 regulation of mitotic spindle organization ISS
 biological_processGO:0090307 mitotic spindle assembly IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0061676 importin-alpha family protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072571 HMMR / O75330 / hyaluronan mediated motility receptor  / complex / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction






 

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