ENSG00000087586


Homo sapiens

Features
Gene ID: ENSG00000087586
  
Biological name :AURKA
  
Synonyms : AURKA / aurora kinase A / O14965
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.2
Gene start: 56369389
Gene end: 56392337
  
Corresponding Affymetrix probe sets: 204092_s_at (Human Genome U133 Plus 2.0 Array)   208079_s_at (Human Genome U133 Plus 2.0 Array)   208080_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393452
Ensembl peptide - ENSP00000388073
Ensembl peptide - ENSP00000401358
Ensembl peptide - ENSP00000405170
Ensembl peptide - ENSP00000405042
Ensembl peptide - ENSP00000216911
Ensembl peptide - ENSP00000321591
Ensembl peptide - ENSP00000360407
Ensembl peptide - ENSP00000379243
Ensembl peptide - ENSP00000379247
Ensembl peptide - ENSP00000379249
Ensembl peptide - ENSP00000379250
Ensembl peptide - ENSP00000379251
NCBI entrez gene - 6790     See in Manteia.
OMIM - 603072
RefSeq - NM_198437
RefSeq - NM_001323303
RefSeq - NM_001323304
RefSeq - NM_001323305
RefSeq - NM_003600
RefSeq - NM_198433
RefSeq - NM_198434
RefSeq - NM_198435
RefSeq - NM_198436
RefSeq - XM_017028034
RefSeq - XM_017028035
RefSeq Peptide - NP_940837
RefSeq Peptide - NP_940838
RefSeq Peptide - NP_940839
RefSeq Peptide - NP_001310234
RefSeq Peptide - NP_003591
RefSeq Peptide - NP_940835
RefSeq Peptide - NP_001310232
RefSeq Peptide - NP_001310233
RefSeq Peptide - NP_940836
swissprot - Q5QPD4
swissprot - A3KFJ2
swissprot - A3KFJ1
swissprot - O14965
swissprot - Q5QPD1
swissprot - Q5QPD2
swissprot - A3KFJ0
Ensembl - ENSG00000087586
  
Related genetic diseases (OMIM): 114500 - {Colon cancer, susceptibility to}, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkaENSDARG00000012485Danio rerio
 AURKAENSGALG00000007768Gallus gallus
 AurkaENSMUSG00000027496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AURKB / Q96GD4 / aurora kinase BENSG0000017899952
AURKC / Q9UQB9 / aurora kinase CENSG0000010514649
STK36 / Q9NRP7 / serine/threonine kinase 36ENSG0000016348222
NEK10 / Q6ZWH5 / NIMA related kinase 10ENSG0000016349120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030611  Aurora kinase A
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000212 meiotic spindle organization IEA
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IMP
 biological_processGO:0007052 mitotic spindle organization IBA
 biological_processGO:0007057 spindle assembly involved in female meiosis I IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007100 mitotic centrosome separation IEA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032465 regulation of cytokinesis IBA
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division TAS
 biological_processGO:0046605 regulation of centrosome cycle TAS
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051642 centrosome localization IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:0097421 liver regeneration IDA
 biological_processGO:1900195 positive regulation of oocyte maturation IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IBA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome TAS
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030496 midbody TAS
 cellular_componentGO:0031616 spindle pole centrosome IDA
 cellular_componentGO:0032133 chromosome passenger complex IBA
 cellular_componentGO:0042585 germinal vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043203 axon hillock IEA
 cellular_componentGO:0045120 pronucleus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0051233 spindle midzone IBA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0072687 meiotic spindle IEA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035174 histone serine kinase activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA replication proteins
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000088325 TPX2 / Q9ULW0 / TPX2, microtubule nucleation factor  / complex / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction / complex
 ENSG00000072571 HMMR / O75330 / hyaluronan mediated motility receptor  / complex / reaction
 ENSG00000116717 P24522 / GADD45A / growth arrest and DNA damage inducible alpha  / complex / reaction
 ENSG00000129474 AJUBA / Q96IF1 / ajuba LIM protein  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000183580 FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7  / reaction / complex
 ENSG00000139289 PHLDA1 / Q8WV24 / pleckstrin homology like domain family A member 1  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / complex / reaction






 

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