ENSG00000183580


Homo sapiens

Features
Gene ID: ENSG00000183580
  
Biological name :FBXL7
  
Synonyms : F-box and leucine rich repeat protein 7 / FBXL7 / Q9UJT9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: p15.1
Gene start: 15500196
Gene end: 15939795
  
Corresponding Affymetrix probe sets: 213249_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329632
Ensembl peptide - ENSP00000423630
Ensembl peptide - ENSP00000425184
NCBI entrez gene - 23194     See in Manteia.
OMIM - 605656
RefSeq - XM_011513998
RefSeq - NM_001278317
RefSeq - NM_012304
RefSeq Peptide - NP_001265246
RefSeq Peptide - NP_036436
swissprot - Q9UJT9
swissprot - J3KNM9
Ensembl - ENSG00000183580
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl7ENSDARG00000062251Danio rerio
 FBXL7ENSGALG00000031947Gallus gallus
 Fbxl7ENSMUSG00000043556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXL20 / Q96IG2 / F-box and leucine rich repeat protein 20ENSG0000010830625
FBXL2 / Q9UKC9 / F-box and leucine rich repeat protein 2ENSG0000015355824
FBXL17 / Q9UF56 / F-box and leucine rich repeat protein 17ENSG0000014574321
FBXL13 / Q8NEE6 / F-box and leucine rich repeat protein 13ENSG0000016104021
FBXL16 / Q8N461 / F-box and leucine rich repeat protein 16ENSG0000012758518
FBXL4 / Q9UKA2 / F-box and leucine rich repeat protein 4ENSG0000011223417
FBXL14 / Q8N1E6 / F-box and leucine rich repeat protein 14ENSG0000017182316
FBXL15 / Q9H469 / F-box and leucine rich repeat protein 15ENSG0000010787214
LRRC29 / Q8WV35 / leucine rich repeat containing 29ENSG000001251229


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0000278 mitotic cell cycle ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process NAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010265 SCF complex assembly TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000151 ubiquitin ligase complex NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction






 

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