ENSMUSG00000043556


Mus musculus

Features
Gene ID: ENSMUSG00000043556
  
Biological name :Fbxl7
  
Synonyms : F-box/LRR-repeat protein 7 / Fbxl7 / Q5BJ29
  
Possible biological names infered from orthology : F-box and leucine rich repeat protein 7 / Q9UJT9
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B1
Gene start: 26540459
Gene end: 26895580
  
Corresponding Affymetrix probe sets: 10427898 (MoGene1.0st)   10427904 (MoGene1.0st)   1439890_at (Mouse Genome 430 2.0 Array)   1440441_at (Mouse Genome 430 2.0 Array)   1456220_at (Mouse Genome 430 2.0 Array)   1458485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061305
NCBI entrez gene - 448987     See in Manteia.
MGI - MGI:3052506
RefSeq - NM_176959
RefSeq Peptide - NP_795933
swissprot - Q5BJ29
Ensembl - ENSMUSG00000043556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl7ENSDARG00000062251Danio rerio
 FBXL7ENSGALG00000031947Gallus gallus
 FBXL7ENSG00000183580Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxl20 / Q9CZV8 / F-box/LRR-repeat protein 20 / Q96IG2* / F-box and leucine rich repeat protein 20*ENSMUSG0000002088325
Fbxl2 / Q8BH16 / F-box/LRR-repeat protein 2 / Q9UKC9* / F-box and leucine rich repeat protein 2*ENSMUSG0000003250723
Fbxl13 / Q8CDU4 / F-box/LRR-repeat protein 13 / Q8NEE6* / F-box and leucine rich repeat protein 13*ENSMUSG0000004852022
Fbxl17 / Q9QZN1 / F-box/LRR-repeat protein 17 / Q9UF56* / F-box and leucine rich repeat protein 17*ENSMUSG0000002396520
A2RT62 / Fbxl16 / F-box/LRR-repeat protein 16 / Q8N461* / F-box and leucine rich repeat protein 16*ENSMUSG0000002573818
Fbxl4 / Q8BH70 / F-box/LRR-repeat protein 4 / Q9UKA2* / F-box and leucine rich repeat protein 4*ENSMUSG0000004041017
Fbxl14 / Q8BID8 / F-box/LRR-repeat protein 14 / Q8N1E6* / F-box and leucine rich repeat protein 14*ENSMUSG0000003001916
Fbxl15 / Q91W61 / F-box/LRR-repeat protein 15 / Q9H469* / F-box and leucine rich repeat protein 15*ENSMUSG0000002522614
Lrrc29 / leucine rich repeat containing 29 / Q8WV35*ENSMUSG000000416798


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027496 Aurka / P97477 / Aurora kinase A / O14965*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex






 

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