ENSG00000153558


Homo sapiens

Features
Gene ID: ENSG00000153558
  
Biological name :FBXL2
  
Synonyms : F-box and leucine rich repeat protein 2 / FBXL2 / Q9UKC9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p22.3
Gene start: 33277025
Gene end: 33403662
  
Corresponding Affymetrix probe sets: 214436_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441228
Ensembl peptide - ENSP00000417601
Ensembl peptide - ENSP00000426163
Ensembl peptide - ENSP00000405084
Ensembl peptide - ENSP00000406737
Ensembl peptide - ENSP00000408895
Ensembl peptide - ENSP00000411273
Ensembl peptide - ENSP00000411484
Ensembl peptide - ENSP00000416332
NCBI entrez gene - 25827     See in Manteia.
OMIM - 605652
RefSeq - XM_017006094
RefSeq - NM_001171713
RefSeq - NM_012157
RefSeq - XM_005265014
RefSeq - XM_005265015
RefSeq - XM_005265016
RefSeq - XM_005265017
RefSeq - XM_011533559
RefSeq - XM_017006092
RefSeq - XM_017006093
RefSeq Peptide - NP_001165184
RefSeq Peptide - NP_036289
swissprot - F8WC58
swissprot - F8WCQ8
swissprot - F8WBS9
swissprot - Q9UKC9
swissprot - F8WB01
swissprot - F8WE99
swissprot - F8WBW7
Ensembl - ENSG00000153558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl2ENSDARG00000012135Danio rerio
 FBXL2ENSGALG00000030175Gallus gallus
 Fbxl2ENSMUSG00000032507Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXL20 / Q96IG2 / F-box and leucine rich repeat protein 20ENSG0000010830678
FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7ENSG0000018358028
FBXL13 / Q8NEE6 / F-box and leucine rich repeat protein 13ENSG0000016104028
FBXL14 / Q8N1E6 / F-box and leucine rich repeat protein 14ENSG0000017182323
FBXL16 / Q8N461 / F-box and leucine rich repeat protein 16ENSG0000012758522
FBXL17 / Q9UF56 / F-box and leucine rich repeat protein 17ENSG0000014574322
FBXL4 / Q9UKA2 / F-box and leucine rich repeat protein 4ENSG0000011223421
FBXL15 / Q9H469 / F-box and leucine rich repeat protein 15ENSG0000010787217
LRRC29 / Q8WV35 / leucine rich repeat containing 29ENSG0000012512210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001810  F-box domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0044830 modulation by host of viral RNA genome replication IMP
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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