ENSG00000105146


Homo sapiens

Features
Gene ID: ENSG00000105146
  
Biological name :AURKC
  
Synonyms : AURKC / aurora kinase C / Q9UQB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.43
Gene start: 57230802
Gene end: 57235548
  
Corresponding Affymetrix probe sets: 211107_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469894
Ensembl peptide - ENSP00000469983
Ensembl peptide - ENSP00000471830
Ensembl peptide - ENSP00000470465
Ensembl peptide - ENSP00000302898
Ensembl peptide - ENSP00000406798
Ensembl peptide - ENSP00000407162
Ensembl peptide - ENSP00000468918
NCBI entrez gene - 6795     See in Manteia.
OMIM - 603495
RefSeq - NM_003160
RefSeq - NM_001015878
RefSeq - NM_001015879
RefSeq Peptide - NP_001015878
RefSeq Peptide - NP_001015879
RefSeq Peptide - NP_003151
swissprot - Q9UQB9
swissprot - A0A0A0MSY3
swissprot - M0QX60
swissprot - M0QYK8
swissprot - Q5Y191
swissprot - B4DXA6
Ensembl - ENSG00000105146
  
Related genetic diseases (OMIM): 243060 - Spermatogenic failure 5, 243060
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkbENSDARG00000037640Danio rerio
 AurkcENSMUSG00000070837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AURKB / Q96GD4 / aurora kinase BENSG0000017899976
AURKA / O14965 / aurora kinase AENSG0000008758664
STK36 / Q9NRP7 / serine/threonine kinase 36ENSG0000016348232
NEK10 / Q6ZWH5 / NIMA related kinase 10ENSG0000016349119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030613  Aurora kinase C
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016570 histone modification TAS
 biological_processGO:0032467 positive regulation of cytokinesis TAS
 biological_processGO:0035404 histone-serine phosphorylation IEA
 biological_processGO:0048599 oocyte development IEA
 biological_processGO:0051255 spindle midzone assembly IEA
 biological_processGO:0051256 mitotic spindle midzone assembly TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IBA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IBA
 cellular_componentGO:0030496 midbody TAS
 cellular_componentGO:0031616 spindle pole centrosome IBA
 cellular_componentGO:0032133 chromosome passenger complex IEA
 cellular_componentGO:0051233 spindle midzone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000025 Functional abnormality of male internal genitalia 
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 HP:0003251 Male infertility 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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