ENSG00000178999


Homo sapiens

Features
Gene ID: ENSG00000178999
  
Biological name :AURKB
  
Synonyms : AURKB / aurora kinase B / Q96GD4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 8204733
Gene end: 8210600
  
Corresponding Affymetrix probe sets: 209464_at (Human Genome U133 Plus 2.0 Array)   239219_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464031
Ensembl peptide - ENSP00000463636
Ensembl peptide - ENSP00000463999
Ensembl peptide - ENSP00000313950
Ensembl peptide - ENSP00000443869
Ensembl peptide - ENSP00000461981
Ensembl peptide - ENSP00000462027
Ensembl peptide - ENSP00000462207
Ensembl peptide - ENSP00000462858
Ensembl peptide - ENSP00000462930
NCBI entrez gene - 9212     See in Manteia.
OMIM - 604970
RefSeq - XM_017025311
RefSeq - NM_001256834
RefSeq - NM_001284526
RefSeq - NM_001313950
RefSeq - NM_001313951
RefSeq - NM_001313952
RefSeq - NM_001313953
RefSeq - NM_001313954
RefSeq - NM_001313955
RefSeq - NM_004217
RefSeq - XM_011524070
RefSeq - XM_011524072
RefSeq - XM_017025307
RefSeq - XM_017025308
RefSeq - XM_017025309
RefSeq - XM_017025310
RefSeq Peptide - NP_001243763
RefSeq Peptide - NP_001300880
RefSeq Peptide - NP_001300881
RefSeq Peptide - NP_001300882
RefSeq Peptide - NP_001300883
RefSeq Peptide - NP_001300884
RefSeq Peptide - NP_004208
RefSeq Peptide - NP_001271455
RefSeq Peptide - NP_001300879
swissprot - J3KRJ2
swissprot - J3KT86
swissprot - J3KTD6
swissprot - J3QLN8
swissprot - J3QR41
swissprot - J3KRF8
swissprot - Q96GD4
Ensembl - ENSG00000178999
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkbENSDARG00000037640Danio rerio
 AurkbENSMUSG00000020897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AURKC / Q9UQB9 / aurora kinase CENSG0000010514668
AURKA / O14965 / aurora kinase AENSG0000008758661
STK36 / Q9NRP7 / serine/threonine kinase 36ENSG0000016348226
NEK10 / Q6ZWH5 / NIMA related kinase 10ENSG0000016349119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028772  Aurora kinase B
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore TAS
 biological_processGO:0009838 abscission ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016570 histone modification TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031577 spindle checkpoint IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032466 negative regulation of cytokinesis ISS
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0034501 protein localization to kinetochore IMP
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0036089 cleavage furrow formation IDA
 biological_processGO:0043988 histone H3-S28 phosphorylation IEA
 biological_processGO:0044878 mitotic cytokinesis checkpoint ISS
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0051256 mitotic spindle midzone assembly TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0051983 regulation of chromosome segregation TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1904355 positive regulation of telomere capping IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IDA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IBA
 cellular_componentGO:0010369 chromocenter IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031616 spindle pole centrosome IBA
 cellular_componentGO:0032133 chromosome passenger complex IEA
 cellular_componentGO:0051233 spindle midzone IBA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0035174 histone serine kinase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Regulation of TP53 Activity through Phosphorylation
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149503 INCENP / Q9NQS7 / inner centromere protein  / complex
 ENSG00000089685 BIRC5 / O15392 / baculoviral IAP repeat containing 5  / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000134690 CDCA8 / Q53HL2 / cell division cycle associated 8  / complex
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction
 ENSG00000188976 NOC2L / Q9Y3T9 / NOC2 like nucleolar associated transcriptional repressor  / complex / reaction






 

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