ENSG00000089685


Homo sapiens

Features
Gene ID: ENSG00000089685
  
Biological name :BIRC5
  
Synonyms : baculoviral IAP repeat containing 5 / BIRC5 / O15392
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 78214186
Gene end: 78225636
  
Corresponding Affymetrix probe sets: 1555826_at (Human Genome U133 Plus 2.0 Array)   202094_at (Human Genome U133 Plus 2.0 Array)   202095_s_at (Human Genome U133 Plus 2.0 Array)   210334_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466675
Ensembl peptide - ENSP00000467336
Ensembl peptide - ENSP00000467259
Ensembl peptide - ENSP00000301633
Ensembl peptide - ENSP00000324180
Ensembl peptide - ENSP00000364086
Ensembl peptide - ENSP00000465868
Ensembl peptide - ENSP00000466063
Ensembl peptide - ENSP00000466617
NCBI entrez gene - 332     See in Manteia.
OMIM - 603352
RefSeq - NM_001168
RefSeq - NM_001012270
RefSeq - NM_001012271
RefSeq Peptide - NP_001012271
RefSeq Peptide - NP_001012270
RefSeq Peptide - NP_001159
swissprot - O15392
swissprot - H3BLT4
swissprot - K7ELG2
swissprot - K7EMW2
swissprot - K7EP76
swissprot - A0A0B4J1S3
Ensembl - ENSG00000089685
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc5aENSDARG00000075621Danio rerio
 BIRC5ENSGALG00000008713Gallus gallus
 Birc5ENSMUSG00000017716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007605 sensory perception of sound IEP
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031503 protein-containing complex localization IMP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation IEA
 biological_processGO:0090307 mitotic spindle assembly IBA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032133 chromosome passenger complex IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding TAS
 molecular_functionGO:0008536 Ran GTPase binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149503 INCENP / Q9NQS7 / inner centromere protein  / complex
 ENSG00000178999 AURKB / Q96GD4 / aurora kinase B  / complex
 ENSG00000134690 CDCA8 / Q53HL2 / cell division cycle associated 8  / complex






 

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