ENSMUSG00000017716


Mus musculus

Features
Gene ID: ENSMUSG00000017716
  
Biological name :Birc5
  
Synonyms : Baculoviral IAP repeat-containing protein 5 / Birc5 / O70201
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 5 / O15392
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 117849251
Gene end: 117855743
  
Corresponding Affymetrix probe sets: 10382998 (MoGene1.0st)   1424278_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079124
Ensembl peptide - ENSMUSP00000091433
NCBI entrez gene - 11799     See in Manteia.
MGI - MGI:1203517
RefSeq - NM_009689
RefSeq - NM_001012273
RefSeq Peptide - NP_001012273
RefSeq Peptide - NP_033819
swissprot - O70201
swissprot - Q549P2
Ensembl - ENSMUSG00000017716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc5aENSDARG00000075621Danio rerio
 BIRC5ENSGALG00000008713Gallus gallus
 BIRC5ENSG00000089685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISS
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0000281 mitotic cytokinesis ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint ISS
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031503 protein-containing complex localization ISO
 biological_processGO:0031536 positive regulation of exit from mitosis ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISS
 biological_processGO:0051301 cell division ISO
 biological_processGO:0051303 establishment of chromosome localization ISO
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation IMP
 biological_processGO:0090307 mitotic spindle assembly IBA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0000228 nuclear chromosome ISO
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule ISS
 cellular_componentGO:0005881 cytoplasmic microtubule ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031021 interphase microtubule organizing center ISO
 cellular_componentGO:0032133 chromosome passenger complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0008536 Ran GTPase binding ISO
 molecular_functionGO:0015631 tubulin binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0048037 cofactor binding ISS
 molecular_functionGO:0051087 chaperone binding ISO


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Birc5tm1Mak/Birc5tm1Mak,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003706 abnormal nucleus count "absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis" [pg:Philip Groth submission]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhotm3(RHO/GFP)Jhw/Rho+
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6-Tyrc)

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Col4a1Raw/Col4a1+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc5tm1Mak/Birc5tm1Mak,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc5tm1Mak/Birc5tm1Mak,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Birc5tm1Mak/Birc5tm1Mak,Tg(Lck-cre)I57Jxm/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: B6.129S4-Ctla4tm1Shr

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020897 Aurkb / O70126 / Aurora kinase B / Q96GD4*  / complex
 ENSMUSG00000024660 Incenp / Q9WU62 / Inner centromere protein / Q9NQS7*  / complex
 ENSMUSG00000028873 Cdca8 / Q8BHX3 / Borealin / Q53HL2* / cell division cycle associated 8*  / complex






 

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