ENSMUSG00000020897


Mus musculus

Features
Gene ID: ENSMUSG00000020897
  
Biological name :Aurkb
  
Synonyms : Aurkb / Aurora kinase B / O70126
  
Possible biological names infered from orthology : Q96GD4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69045647
Gene end: 69051664
  
Corresponding Affymetrix probe sets: 10377405 (MoGene1.0st)   1424128_x_at (Mouse Genome 430 2.0 Array)   1451246_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021277
Ensembl peptide - ENSMUSP00000104306
NCBI entrez gene - 20877     See in Manteia.
MGI - MGI:107168
RefSeq - XM_006532725
RefSeq - NM_011496
RefSeq Peptide - NP_035626
swissprot - O70126
Ensembl - ENSMUSG00000020897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aurkbENSDARG00000037640Danio rerio
 AURKBENSG00000178999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aurkc / Q9UQB9* / aurora kinase C*ENSMUSG0000007083762
Aurka / P97477 / Aurora kinase A / O14965*ENSMUSG0000002749659
Stk36 / Q69ZM6 / serine/threonine kinase 36 / Q9NRP7*ENSMUSG0000003327627
Nek10 / Q3UGM2 / Serine/threonine-protein kinase Nek10 / Q6ZWH5* / NIMA related kinase 10*ENSMUSG0000004256723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028772  Aurora kinase B
 IPR030616  Aurora kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007051 spindle organization IEA
 biological_processGO:0007052 mitotic spindle organization IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009838 abscission ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031577 spindle checkpoint IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032465 regulation of cytokinesis IBA
 biological_processGO:0032466 negative regulation of cytokinesis ISS
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0036089 cleavage furrow formation IEA
 biological_processGO:0043988 histone H3-S28 phosphorylation IDA
 biological_processGO:0044878 mitotic cytokinesis checkpoint ISS
 biological_processGO:0051256 mitotic spindle midzone assembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000779 condensed chromosome, centromeric region IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IBA
 cellular_componentGO:0010369 chromocenter IDA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031616 spindle pole centrosome IBA
 cellular_componentGO:0032133 chromosome passenger complex ISO
 cellular_componentGO:1990023 mitotic spindle midzone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0035174 histone serine kinase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Regulation of TP53 Activity through Phosphorylation
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0003707 increased nucleus count "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Aurkbtm1.1Mama/Aurkbtm1.1Mama
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Aurkbtm1.1Mama/Aurkbtm1.1Mama
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

 MP:0005032 abnormal ectoplacental cone 
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0009591 liver adenocarcinoma "malignant neoplasm of epithelial cells in the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Aurkbtm1.1Mama/Aurkbtm1.1Mama
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Aurkbtm1.1Mama/Aurkbtm1.1Mama
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * SJL

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000017716 Birc5 / O70201 / Baculoviral IAP repeat-containing protein 5 / O15392* / baculoviral IAP repeat containing 5*  / complex
 ENSMUSG00000024660 Incenp / Q9WU62 / Inner centromere protein / Q9NQS7*  / complex
 ENSMUSG00000028873 Cdca8 / Q8BHX3 / Borealin / Q53HL2* / cell division cycle associated 8*  / complex
 ENSMUSG00000095567 Noc2l / NOC2 like nucleolar associated transcriptional repressor / Q9Y3T9*  / reaction / complex






 

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