ENSMUSG00000095567


Mus musculus

Features
Gene ID: ENSMUSG00000095567
  
Biological name :Noc2l
  
Synonyms : Noc2l / NOC2 like nucleolar associated transcriptional repressor
  
Possible biological names infered from orthology : Q9Y3T9
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 156236010
Gene end: 156247616
  
Corresponding Affymetrix probe sets: 10608699 (MoGene1.0st)   1424323_at (Mouse Genome 430 2.0 Array)   1436136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137183
Ensembl peptide - ENSMUSP00000137253
NCBI entrez gene - 57741     See in Manteia.
MGI - MGI:1931051
RefSeq - NM_021303
RefSeq Peptide - NP_067278
swissprot - J3QK52
swissprot - Q8BHX6
Ensembl - ENSMUSG00000095567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 noc2lENSDARG00000001754Danio rerio
 NOC2LENSGALG00000002222Gallus gallus
 NOC2LENSG00000188976Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005343  Nucleolar complex protein 2
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002903 negative regulation of B cell apoptotic process IEA
 biological_processGO:0031497 chromatin assembly IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Noc2ltm1.1Arte/Noc2ltm1.1Arte,Trp53tm1Brn/Trp53tm1Brn,Tg(CD2-icre)4Kio/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010134 decreased DN3 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Tg(VDR*L233S,luc)T807Pike/0,Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000020897 Aurkb / O70126 / Aurora kinase B / Q96GD4*  / complex / reaction






 

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