ENSMUSG00000024660


Mus musculus

Features
Gene ID: ENSMUSG00000024660
  
Biological name :Incenp
  
Synonyms : Incenp / Inner centromere protein / Q9WU62
  
Possible biological names infered from orthology : Q9NQS7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 9872297
Gene end: 9899533
  
Corresponding Affymetrix probe sets: 10465861 (MoGene1.0st)   1423092_at (Mouse Genome 430 2.0 Array)   1423093_at (Mouse Genome 430 2.0 Array)   1439252_at (Mouse Genome 430 2.0 Array)   1439436_x_at (Mouse Genome 430 2.0 Array)   1441314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025562
NCBI entrez gene - 16319     See in Manteia.
MGI - MGI:1313288
RefSeq - XM_011247154
RefSeq - NM_016692
RefSeq - XM_006526710
RefSeq - XM_006526712
RefSeq - XM_006526707
RefSeq - XM_006526708
RefSeq Peptide - NP_057901
swissprot - Q9WU62
Ensembl - ENSMUSG00000024660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058261.1ENSDARG00000099194Danio rerio
 ENSGALG00000007525Gallus gallus
 INCENPENSGALG00000007537Gallus gallus
 INCENPENSG00000149503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005635  Inner centromere protein, ARK-binding domain
 IPR022006  Chromosome passenger complex (CPC) protein INCENP N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0000801 central element IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0010369 chromocenter IDA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0032991 protein-containing complex IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020897 Aurkb / O70126 / Aurora kinase B / Q96GD4*  / complex
 ENSMUSG00000017716 Birc5 / O70201 / Baculoviral IAP repeat-containing protein 5 / O15392* / baculoviral IAP repeat containing 5*  / complex
 ENSMUSG00000028873 Cdca8 / Q8BHX3 / Borealin / Q53HL2* / cell division cycle associated 8*  / complex






 

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