ENSG00000149503


Homo sapiens

Features
Gene ID: ENSG00000149503
  
Biological name :INCENP
  
Synonyms : INCENP / inner centromere protein / Q9NQS7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.3
Gene start: 62123973
Gene end: 62153163
  
Corresponding Affymetrix probe sets: 219769_at (Human Genome U133 Plus 2.0 Array)   242787_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433100
Ensembl peptide - ENSP00000278849
Ensembl peptide - ENSP00000378295
NCBI entrez gene - 3619     See in Manteia.
OMIM - 604411
RefSeq - XM_011544998
RefSeq - NM_001040694
RefSeq - NM_020238
RefSeq - XM_006718533
RefSeq - XM_011544995
RefSeq - XM_011544996
RefSeq - XM_011544997
RefSeq Peptide - NP_001035784
RefSeq Peptide - NP_064623
swissprot - Q9NQS7
swissprot - E9PM67
Ensembl - ENSG00000149503
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01058261.1ENSDARG00000099194Danio rerio
 ENSGALG00000007525Gallus gallus
 INCENPENSGALG00000007537Gallus gallus
 IncenpENSMUSG00000024660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005635  Inner centromere protein, ARK-binding domain
 IPR022006  Chromosome passenger complex (CPC) protein INCENP N-terminal
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0000801 central element IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005721 pericentric heterochromatin IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0010369 chromocenter IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000178999 AURKB / Q96GD4 / aurora kinase B  / complex
 ENSG00000089685 BIRC5 / O15392 / baculoviral IAP repeat containing 5  / complex
 ENSG00000134690 CDCA8 / Q53HL2 / cell division cycle associated 8  / complex






 

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