ENSG00000134690


Homo sapiens

Features
Gene ID: ENSG00000134690
  
Biological name :CDCA8
  
Synonyms : CDCA8 / cell division cycle associated 8 / Q53HL2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.3
Gene start: 37692418
Gene end: 37709719
  
Corresponding Affymetrix probe sets: 221520_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000316121
Ensembl peptide - ENSP00000362146
NCBI entrez gene - 55143     See in Manteia.
OMIM - 609977
RefSeq - NM_001256875
RefSeq - NM_018101
RefSeq Peptide - NP_001243804
RefSeq Peptide - NP_060571
swissprot - Q53HL2
Ensembl - ENSG00000134690
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdca8ENSDARG00000043137Danio rerio
 Cdca8ENSMUSG00000028873Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018851  Borealin, N-terminal
 IPR018867  Cell division protein borealin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007080 mitotic metaphase plate congression IMP
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0010369 chromocenter IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032133 chromosome passenger complex IPI
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0051233 spindle midzone IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149503 INCENP / Q9NQS7 / inner centromere protein  / complex
 ENSG00000089685 BIRC5 / O15392 / baculoviral IAP repeat containing 5  / complex
 ENSG00000178999 AURKB / Q96GD4 / aurora kinase B  / complex






 

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