ENSG00000116717


Homo sapiens

Features
Gene ID: ENSG00000116717
  
Biological name :GADD45A
  
Synonyms : GADD45A / growth arrest and DNA damage inducible alpha / P24522
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 67685061
Gene end: 67688338
  
Corresponding Affymetrix probe sets: 203725_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482814
Ensembl peptide - ENSP00000360024
Ensembl peptide - ENSP00000360025
NCBI entrez gene - 1647     See in Manteia.
OMIM - 126335
RefSeq - NM_001199741
RefSeq - NM_001199742
RefSeq - NM_001924
RefSeq Peptide - NP_001186670
RefSeq Peptide - NP_001186671
RefSeq Peptide - NP_001915
swissprot - P24522
swissprot - A5JUZ3
Ensembl - ENSG00000116717
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gadd45aaENSDARG00000043581Danio rerio
 gadd45abENSDARG00000104571Danio rerio
 GADD45AENSGALG00000025977Gallus gallus
 P48316ENSMUSG00000036390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75293 / GADD45B / growth arrest and DNA damage inducible betaENSG0000009986055
O95257 / GADD45G / growth arrest and DNA damage inducible gammaENSG0000013022255


Protein motifs (from Interpro)
Interpro ID Name
 IPR004038  Ribosomal protein L7Ae/L30e/S12e/Gadd45
 IPR024824  Growth arrest and DNA damage-inducible protein GADD45
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000185 activation of MAPKKK activity IDA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IMP
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0047485 protein N-terminus binding IDA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction






 

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