ENSG00000007908


Homo sapiens

Features
Gene ID: ENSG00000007908
  
Biological name :SELE
  
Synonyms : P16581 / SELE / selectin E
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.2
Gene start: 169722641
Gene end: 169764705
  
Corresponding Affymetrix probe sets: 206211_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476784
Ensembl peptide - ENSP00000356750
Ensembl peptide - ENSP00000356751
Ensembl peptide - ENSP00000331736
Ensembl peptide - ENSP00000356748
Ensembl peptide - ENSP00000356749
NCBI entrez gene - 6401     See in Manteia.
OMIM - 131210
RefSeq - NM_000450
RefSeq Peptide - NP_000441
swissprot - P16581
swissprot - Q5TI72
swissprot - Q5TI73
swissprot - Q5TI74
swissprot - Q5TI75
swissprot - V9GYI4
Ensembl - ENSG00000007908
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 seleENSDARG00000009123Danio rerio
 SELEENSGALG00000031430Gallus gallus
 SeleENSMUSG00000026582Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SELP / P16109 / selectin PENSG0000017417544
SELL / P14151 / selectin LENSG0000018840427
CFH / P08603 / complement factor HENSG0000000097119
F13B / P05160 / coagulation factor XIII B chainENSG0000014327816
C4BPA / P04003 / complement component 4 binding protein alphaENSG0000012383815
CFHR5 / Q9BXR6 / complement factor H related 5ENSG0000013438915
APOH / P02749 / apolipoprotein HENSG0000009158310
CD46 / P15529 / CD46 moleculeENSG0000011733510
CFHR4 / Q92496 / complement factor H related 4ENSG0000013436510
CFHR1 / Q03591 / complement factor H related 1ENSG000002444149
CD55 / P08174 / CD55 molecule (Cromer blood group)ENSG000001963527
CFHR2 / P36980 / complement factor H related 2ENSG000000809107
BX248415.1ENSG000002769117
CFHR3 / Q02985 / complement factor H related 3ENSG000001167855


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR002396  Selectin superfamily
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033991  Selectin, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007202 activation of phospholipase C activity IMP
 biological_processGO:0019722 calcium-mediated signaling TAS
 biological_processGO:0030029 actin filament-based process IDA
 biological_processGO:0032496 response to lipopolysaccharide TAS
 biological_processGO:0034612 response to tumor necrosis factor TAS
 biological_processGO:0050727 regulation of inflammatory response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 biological_processGO:0070555 response to interleukin-1 IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0043274 phospholipase binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070492 oligosaccharide binding IDA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110876 Q14242 / SELPLG / selectin P ligand  / reaction / complex
 ENSG00000090863 GLG1 / Q92896 / golgi glycoprotein 1  / complex / reaction
 ENSG00000026508 CD44 / P16070 / CD44 molecule (Indian blood group)  / reaction / complex
 ENSG00000197471 SPN / P16150 / sialophorin  / complex / reaction






 

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