ENSG00000188404


Homo sapiens

Features
Gene ID: ENSG00000188404
  
Biological name :SELL
  
Synonyms : P14151 / selectin L / SELL
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.2
Gene start: 169690667
Gene end: 169711698
  
Corresponding Affymetrix probe sets: 204563_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000236147
NCBI entrez gene - 6402     See in Manteia.
OMIM - 153240
RefSeq - NM_000655
RefSeq Peptide - NP_000646
swissprot - A0A024R8Z0
swissprot - P14151
Ensembl - ENSG00000188404
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selpENSDARG00000042138Danio rerio
 SellENSMUSG00000026581Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SELP / P16109 / selectin PENSG0000017417545
SELE / P16581 / selectin EENSG0000000790843
F13B / P05160 / coagulation factor XIII B chainENSG0000014327815
CFH / P08603 / complement factor HENSG0000000097113
C4BPA / P04003 / complement component 4 binding protein alphaENSG0000012383813
CFHR5 / Q9BXR6 / complement factor H related 5ENSG0000013438912
CD46 / P15529 / CD46 moleculeENSG0000011733512
APOH / P02749 / apolipoprotein HENSG0000009158311
CD55 / P08174 / CD55 molecule (Cromer blood group)ENSG0000019635210
CFHR4 / Q92496 / complement factor H related 4ENSG000001343658
CFHR1 / Q03591 / complement factor H related 1ENSG000002444147
BX248415.1ENSG000002769117
CFHR2 / P36980 / complement factor H related 2ENSG000000809107
CFHR3 / Q02985 / complement factor H related 3ENSG000001167854


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR002396  Selectin superfamily
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR016348  L-selectin
 IPR018378  C-type lectin, conserved site
 IPR033991  Selectin, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding TAS
 molecular_functionGO:0030246 carbohydrate binding TAS
 molecular_functionGO:0043208 glycosphingolipid binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0070492 oligosaccharide binding IMP


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110876 Q14242 / SELPLG / selectin P ligand  / reaction / complex
 ENSG00000099866 Q13477 / MADCAM1 / mucosal vascular addressin cell adhesion molecule 1  / complex / reaction
 ENSG00000174059 CD34 / P28906 / CD34 molecule  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr