ENSG00000174175


Homo sapiens

Features
Gene ID: ENSG00000174175
  
Biological name :SELP
  
Synonyms : P16109 / selectin P / SELP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q24.2
Gene start: 169588849
Gene end: 169630193
  
Corresponding Affymetrix probe sets: 206049_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391694
Ensembl peptide - ENSP00000356769
Ensembl peptide - ENSP00000399368
Ensembl peptide - ENSP00000263686
Ensembl peptide - ENSP00000356760
Ensembl peptide - ENSP00000356762
NCBI entrez gene - 6403     See in Manteia.
OMIM - 173610
RefSeq - XM_005245440
RefSeq - NM_003005
RefSeq - XM_005245435
RefSeq - XM_005245436
RefSeq - XM_005245438
RefSeq - XM_005245439
RefSeq Peptide - NP_002996
swissprot - Q5R345
swissprot - Q5R349
swissprot - F6VVT6
swissprot - A0A024R8Y9
swissprot - P16109
swissprot - Q5R342
swissprot - Q5R341
Ensembl - ENSG00000174175
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selpENSDARG00000042138Danio rerio
 ENSGALG00000002643Gallus gallus
 SelpENSMUSG00000026580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SELE / P16581 / selectin EENSG0000000790833
SELL / P14151 / selectin LENSG0000018840421
CFH / P08603 / complement factor HENSG0000000097118
F13B / P05160 / coagulation factor XIII B chainENSG0000014327815
CFHR5 / Q9BXR6 / complement factor H related 5ENSG0000013438912
C4BPA / P04003 / complement component 4 binding protein alphaENSG0000012383812
CFHR4 / Q92496 / complement factor H related 4ENSG0000013436511
APOH / P02749 / apolipoprotein HENSG000000915838
CD46 / P15529 / CD46 moleculeENSG000001173358
CFHR1 / Q03591 / complement factor H related 1ENSG000002444146
CFHR2 / P36980 / complement factor H related 2ENSG000000809105
CFHR3 / Q02985 / complement factor H related 3ENSG000001167855
CD55 / P08174 / CD55 molecule (Cromer blood group)ENSG000001963525
BX248415.1ENSG000002769115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR002396  Selectin superfamily
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033991  Selectin, C-type lectin-like domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0010572 positive regulation of platelet activation ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
 biological_processGO:0032496 response to lipopolysaccharide IC
 biological_processGO:0033623 regulation of integrin activation IMP
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IGI
 biological_processGO:0050829 defense response to Gram-negative bacterium IC
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031088 platelet dense granule membrane TAS
 cellular_componentGO:0031092 platelet alpha granule membrane IDA
 molecular_functionGO:0001530 lipopolysaccharide binding IMP
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0042806 fucose binding IDA
 molecular_functionGO:0043208 glycosphingolipid binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0070492 oligosaccharide binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110876 Q14242 / SELPLG / selectin P ligand  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr