ENSG00000123838


Homo sapiens

Features
Gene ID: ENSG00000123838
  
Biological name :C4BPA
  
Synonyms : C4BPA / complement component 4 binding protein alpha / P04003
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.2
Gene start: 207104262
Gene end: 207144972
  
Corresponding Affymetrix probe sets: 205654_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403386
Ensembl peptide - ENSP00000356037
Ensembl peptide - ENSP00000395968
NCBI entrez gene - 722     See in Manteia.
OMIM - 120830
RefSeq - XM_005273252
RefSeq - NM_000715
RefSeq - XM_005273251
RefSeq Peptide - NP_000706
swissprot - P04003
swissprot - F2Z2V7
swissprot - A6PVY5
Ensembl - ENSG00000123838
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rca2.1ENSDARG00000056075Danio rerio
 rca2.2ENSDARG00000095512Danio rerio
 C4BPAENSGALG00000001175Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CFH / P08603 / complement factor HENSG0000000097123
CD46 / P15529 / CD46 moleculeENSG0000011733520
SELP / P16109 / selectin PENSG0000017417517
F13B / P05160 / coagulation factor XIII B chainENSG0000014327817
APOH / P02749 / apolipoprotein HENSG0000009158316
CD55 / P08174 / CD55 molecule (Cromer blood group)ENSG0000019635216
SELE / P16581 / selectin EENSG0000000790815
CFHR5 / Q9BXR6 / complement factor H related 5ENSG0000013438914
CFHR4 / Q92496 / complement factor H related 4ENSG0000013436513
CFHR1 / Q03591 / complement factor H related 1ENSG0000024441411
BX248415.1ENSG000002769119
CFHR2 / P36980 / complement factor H related 2ENSG000000809109
SELL / P14151 / selectin LENSG000001884048
CFHR3 / Q02985 / complement factor H related 3ENSG000001167857


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045959 negative regulation of complement activation, classical pathway IDA
 biological_processGO:1903027 regulation of opsonization IC
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0044216 other organism cell IDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184500 PROS1 / P07225 / protein S  / reaction / complex
 ENSG00000224389 C4B / P0C0L5 / complement C4B (Chido blood group)  / complex / reaction
 ENSG00000244731 C4A / P0C0L4 / complement C4A (Rodgers blood group)  / reaction / complex
 ENSG00000166278 C2 / P06681 / complement C2  / complex
 ENSG00000123843 C4BPB / P20851 / complement component 4 binding protein beta  / complex
 ENSG00000123838 C4BPA / P04003 / complement component 4 binding protein alpha  / complex
 ENSG00000205403 CFI / P05156 / complement factor I  / reaction / complex






 

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