ENSG00000186792


Homo sapiens

Features
Gene ID: ENSG00000186792
  
Biological name :HYAL3
  
Synonyms : HYAL3 / hyaluronoglucosaminidase 3 / O43820
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 50292831
Gene end: 50299468
  
Corresponding Affymetrix probe sets: 211728_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401092
Ensembl peptide - ENSP00000391922
Ensembl peptide - ENSP00000424633
Ensembl peptide - ENSP00000479935
Ensembl peptide - ENSP00000337425
Ensembl peptide - ENSP00000351946
Ensembl peptide - ENSP00000391663
NCBI entrez gene - 8372     See in Manteia.
OMIM - 604038
RefSeq - NM_001200029
RefSeq - NM_001200030
RefSeq - NM_001200031
RefSeq - NM_001200032
RefSeq - NM_003549
RefSeq Peptide - NP_003540
RefSeq Peptide - NP_001186959
RefSeq Peptide - NP_001186960
RefSeq Peptide - NP_001186961
RefSeq Peptide - NP_001186958
swissprot - O43820
swissprot - C9JB51
swissprot - A0A024R2Y7
Ensembl - ENSG00000186792
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyal3ENSDARG00000036818Danio rerio
 HYAL3ENSGALG00000029000Gallus gallus
 Hyal3ENSMUSG00000036091Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HYAL1 / Q12794 / hyaluronoglucosaminidase 1ENSG0000011437842
HYAL2 / Q12891 / hyaluronoglucosaminidase 2ENSG0000006800142
SPAM1 / P38567 / sperm adhesion molecule 1ENSG0000010630437
HYAL4 / Q2M3T9 / hyaluronoglucosaminidase 4ENSG0000010630237


Protein motifs (from Interpro)
Interpro ID Name
 IPR013785  Aldolase-type TIM barrel
 IPR017853  Glycoside hydrolase superfamily
 IPR018155  Hyaluronidase
 IPR027260  Hyaluronidase-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001552 ovarian follicle atresia ISS
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007341 penetration of zona pellucida ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0030214 hyaluronan catabolic process IEA
 biological_processGO:0046677 response to antibiotic IEP
 biological_processGO:0051216 cartilage development IEP
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071493 cellular response to UV-B IDA
 biological_processGO:2000355 negative regulation of ovarian follicle development ISS
 biological_processGO:2000368 positive regulation of acrosomal vesicle exocytosis ISS
 cellular_componentGO:0001669 acrosomal vesicle ISS
 cellular_componentGO:0002080 acrosomal membrane ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0097225 sperm midpiece ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004415 hyalurononglucosaminidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0033906 hyaluronoglucuronidase activity IDA


Pathways (from Reactome)
Pathway description
CS/DS degradation
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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