ENSG00000132692


Homo sapiens

Features
Gene ID: ENSG00000132692
  
Biological name :BCAN
  
Synonyms : BCAN / brevican / Q96GW7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.1
Gene start: 156641390
Gene end: 156659532
  
Corresponding Affymetrix probe sets: 219107_at (Human Genome U133 Plus 2.0 Array)   221623_at (Human Genome U133 Plus 2.0 Array)   91920_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476509
Ensembl peptide - ENSP00000331210
Ensembl peptide - ENSP00000401709
Ensembl peptide - ENSP00000476259
Ensembl peptide - ENSP00000354925
Ensembl peptide - ENSP00000389898
Ensembl peptide - ENSP00000392731
NCBI entrez gene - 63827     See in Manteia.
OMIM - 600347
RefSeq - XM_017002047
RefSeq - NM_021948
RefSeq - NM_198427
RefSeq - XM_011509866
RefSeq Peptide - NP_068767
RefSeq Peptide - NP_940819
swissprot - Q5T3I8
swissprot - Q96GW7
swissprot - Q5T3I6
swissprot - V9GY88
swissprot - V9GXZ8
swissprot - Q5T3I7
Ensembl - ENSG00000132692
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcanENSDARG00000099412Danio rerio
 BCANENSGALG00000045469Gallus gallus
 BcanENSMUSG00000004892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACAN / aggrecanENSG0000015776641
VCAN / P13611 / versicanENSG0000003842739
NCAN / O14594 / neurocanENSG0000013028737
STAB1 / Q9NY15 / stabilin 1ENSG0000001032719
STAB2 / Q8WWQ8 / stabilin 2ENSG0000013601118
HAPLN3 / Q96S86 / hyaluronan and proteoglycan link protein 3ENSG0000014051116
HAPLN1 / P10915 / hyaluronan and proteoglycan link protein 1ENSG0000014568115
HAPLN4 / Q86UW8 / hyaluronan and proteoglycan link protein 4ENSG0000018766414
HAPLN2 / Q9GZV7 / hyaluronan and proteoglycan link protein 2ENSG0000013270214
P98066 / TNFAIP6 / TNF alpha induced protein 6ENSG000001236107


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000538  Link domain
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0030206 chondroitin sulfate biosynthetic process TAS
 biological_processGO:0030207 chondroitin sulfate catabolic process TAS
 biological_processGO:0030208 dermatan sulfate biosynthetic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0005201 extracellular matrix structural constituent IBA
 molecular_functionGO:0005540 hyaluronic acid binding IBA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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