ENSMUSG00000032125


Mus musculus

Features
Gene ID: ENSMUSG00000032125
  
Biological name :Robo4
  
Synonyms : Robo4 / roundabout guidance receptor 4
  
Possible biological names infered from orthology : Q8WZ75
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 37401897
Gene end: 37415115
  
Corresponding Affymetrix probe sets: 10584288 (MoGene1.0st)   1426206_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099959
Ensembl peptide - ENSMUSP00000150722
Ensembl peptide - ENSMUSP00000150053
Ensembl peptide - ENSMUSP00000110700
Ensembl peptide - ENSMUSP00000110698
NCBI entrez gene - 74144     See in Manteia.
MGI - MGI:1921394
RefSeq - XM_011242615
RefSeq - NM_001309390
RefSeq - NM_028783
RefSeq - XM_006510644
RefSeq - XM_006510645
RefSeq - XM_006510647
RefSeq Peptide - NP_001296319
RefSeq Peptide - NP_083059
swissprot - E9QN68
swissprot - A0A0R4J197
swissprot - D3Z4M4
swissprot - A0A1L1SSV2
swissprot - A0A1L1SUF8
Ensembl - ENSMUSG00000032125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 robo4ENSDARG00000009387Danio rerio
 ENSGALG00000043088Gallus gallus
 ROBO4ENSG00000154133Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Robo1 / roundabout guidance receptor 1 / Q9Y6N7*ENSMUSG0000002288329
Robo2 / roundabout guidance receptor 2 / Q9HCK4*ENSMUSG0000005251624
Robo3 / roundabout guidance receptor 3 / Q96MS0*ENSMUSG0000003212823
Cdon / Q32MD9 / Cell adhesion molecule-related/down-regulated by oncos / Q4KMG0* / cell adhesion associated, oncogene regulated*ENSMUSG0000003811912
Boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSMUSG0000002268712
Ncam2 / O35136 / Neural cell adhesion molecule 2 / O15394*ENSMUSG000000227628
Ncam1 / neural cell adhesion molecule 1 isoform 3 / P13591* / neural cell adhesion molecule 1*ENSMUSG000000395428


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Rorcm1Btlr/Rorcm1Btlr
Genetic Background: C57BL/6J-Rorcm1Btlr

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Ndst1tm1Je/Ndst1tm1Je,Robo4tm1Kzh/Robo4tm1Kzh,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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