ENSDARG00000014891


Danio rerio

Features
Gene ID: ENSDARG00000014891
  
Biological name :robo2
  
Synonyms : robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 39096736
Gene end: 39228226
  
Corresponding Affymetrix probe sets: Dr.12403.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000012875
Ensembl peptide - ENSDARP00000109639
swissprot - F1QBD4
swissprot - F1QEH0
ZFIN ID - ZDB-GENE-001019-1
Ensembl - ENSDARG00000014891
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028863Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
robo1 / roundabout, axon guidance receptor, homolog 1 (Drosophila) / Q9Y6N7* / roundabout guidance receptor 1*ENSDARG0000002678448
robo3 / roundabout, axon guidance receptor, homolog 3 (Drosophila) / Q96MS0* / roundabout guidance receptor 3*ENSDARG0000000564542
robo4 / roundabout, axon guidance receptor, homolog 4 (Drosophila) / Q8WZ75* / roundabout guidance receptor 4*ENSDARG0000000938716
ncam1a / neural cell adhesion molecule 1a / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000005618113
boc / BOC cell adhesion associated, oncogene regulated / Q9BWV1*ENSDARG0000007433512
ncam1b / neural cell adhesion molecule 1b / NCAM1* / P13591* / neural cell adhesion molecule 1* / neural cell adhesion molecule 1 isoform 3 *ENSDARG0000000722012
cdon / cell adhesion associated, oncogene regulated / Q32MD9* / Q4KMG0* / Cell adhesion molecule-related/down-regulated by oncos *ENSDARG0000006132812
ncam2 / neural cell adhesion molecule 2 / O15394* / O35136*ENSDARG0000001746610
ncam3 / neural cell adhesion molecule 3ENSDARG000000895869
BX908388.2ENSDARG000001137744
zgc:77784 / ROBO3* / Q96MS0* / roundabout guidance receptor 3*ENSDARG000000426461
robo2 / roundabout, axon guidance receptor, homolog 2 (Drosophila)ENSDARG000000783660


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR032985  Roundabout homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0016199 axon midline choice point recognition IGI
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0035385 Roundabout signaling pathway IEA
 biological_processGO:0048696 regulation of collateral sprouting in absence of injury IGI
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030673 axolemma IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000059 postoptic commissure postoptic commissure decreased width , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion axon collateral increased length , abnormal
trigeminal ganglion axon increased branchiness , abnormal
trigeminal ganglion sensory neuron has extra parts of type sensory neuron presynaptic active zone, abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000405 cranial nerve III cranial nerve III mislocalised , abnormal
Show

 ZFA:0000556 optic chiasm optic chiasm axon morphology , abnormal
Show

 ZFA:0001657 supraoptic tract supraoptic tract misrouted , abnormal
supraoptic tract axon extension process quality , abnormal
Show

 ZFA:0001659 diencephalic nucleus diencephalic nucleus axon displaced to hindbrain medial region, abnormal
Show

 ZFA:0005778 hypocretin-secreting neuron hypocretin-secreting neuron axon displaced to hindbrain medial region, abnormal
Show

 ZFA:0007001 dorso-rostral cluster dorso-rostral cluster neuron projection mislocalised , abnormal
dorso-rostral cluster neuron projection misrouted , abnormal
dorso-rostral cluster axon extension process quality , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron axon mislocalised medially , abnormal
dopaminergic neuron axon adjacent to hindbrain anterior-posterior axis, abnormal
dopaminergic neuron axon adjacent to spinal cord anterior-posterior axis, abnormal
dopaminergic neuron axon adjacent to spinal cord axis, abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon mislocalised , abnormal
retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon physical object quality , abnormal
retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon displaced to diencephalon ventral region, abnormal
retinal ganglion cell axon displaced to hindbrain , abnormal
retinal ganglion cell axon displaced to telencephalon , abnormal
retinal ganglion cell axon displaced to eye contralateral side, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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