ENSG00000114302


Homo sapiens

Features
Gene ID: ENSG00000114302
  
Biological name :PRKAR2A
  
Synonyms : P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 48744597
Gene end: 48847846
  
Corresponding Affymetrix probe sets: 204842_x_at (Human Genome U133 Plus 2.0 Array)   204843_s_at (Human Genome U133 Plus 2.0 Array)   213052_at (Human Genome U133 Plus 2.0 Array)   225000_at (Human Genome U133 Plus 2.0 Array)   225011_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400840
Ensembl peptide - ENSP00000394041
Ensembl peptide - ENSP00000409239
Ensembl peptide - ENSP00000416438
Ensembl peptide - ENSP00000411432
Ensembl peptide - ENSP00000265563
Ensembl peptide - ENSP00000296446
NCBI entrez gene - 5576     See in Manteia.
OMIM - 176910
RefSeq - XM_017006816
RefSeq - NM_001321982
RefSeq - NM_001321983
RefSeq - NM_001321989
RefSeq - NM_004157
RefSeq - XM_005265315
RefSeq - XM_011533942
RefSeq - XM_011533943
RefSeq - XM_017006815
RefSeq Peptide - NP_001308911
RefSeq Peptide - NP_001308918
RefSeq Peptide - NP_004148
RefSeq Peptide - NP_001308912
swissprot - H7C330
swissprot - H7C4A9
swissprot - A0A024R2W3
swissprot - P13861
swissprot - C9J830
swissprot - A0A0S2Z472
swissprot - H7C1L0
Ensembl - ENSG00000114302
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar2aaENSDARG00000033184Danio rerio
 prkar2abENSDARG00000009477Danio rerio
 PRKAR2AENSGALG00000007023Gallus gallus
 Prkar2aENSMUSG00000032601Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit betaENSG0000000524968
P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit betaENSG0000018819136
P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alphaENSG0000010894636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012105  Sperm surface protein Sp17
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097546 ciliary base TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity NAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
ROBO receptors bind AKAP5
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108599 AKAP10 / O43572 / A-kinase anchoring protein 10  / complex / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / reaction / complex
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / reaction / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex






 

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