ENSGALG00000007023


Gallus gallus

Features
Gene ID: ENSGALG00000007023
  
Biological name :PRKAR2A
  
Synonyms : PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha
  
Possible biological names infered from orthology : P13861 / protein kinase, cAMP dependent regulatory, type II alpha
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 11759446
Gene end: 11808025
  
Corresponding Affymetrix probe sets: Gga.9064.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011344
NCBI entrez gene - 100858827     See in Manteia.
RefSeq - XM_003642006
RefSeq - XM_015293315
swissprot - E1C9H8
Ensembl - ENSGALG00000007023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar2aaENSDARG00000033184Danio rerio
 prkar2abENSDARG00000009477Danio rerio
 P13861ENSG00000114302Homo sapiens
 Prkar2aENSMUSG00000032601Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta / P31323* / P31324* / protein kinase, cAMP dependent regulatory, type II beta*ENSGALG0000000806068
Q5ZM91 / PRKAR1A / cAMP-dependent protein kinase type I-alpha regulatory subunit / Q9DBC7* / P10644* / protein kinase, cAMP dependent regulatory, type I, alpha* / protein kinase cAMP-depen...ENSGALG0000000423734
PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta / P12849* / P31321* / protein kinase, cAMP dependent regulatory, type I beta*ENSGALG0000000367533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IEA
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003675 PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta / P12849* / P31321* / protein kinase, cAMP dependent regulatory, type I beta*  / complex
 ENSGALG00000007023 PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha / P13861* / protein kinase, cAMP dependent regulatory, type II alpha*  / complex
 ENSGALG00000005575 AKAP1 / A-kinase anchoring protein 1 / O08715* / Q92667* / A-kinase anchor protein 1, mitochondrial *  / complex / reaction
 ENSGALG00000004237 Q5ZM91 / PRKAR1A / cAMP-dependent protein kinase type I-alpha regulatory subunit / Q9DBC7* / P10644* / protein kinase, cAMP dependent regulatory, type I, alpha* / protein kinase cAMP-depen...  / complex






 

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