ENSMUSG00000032601


Mus musculus

Features
Gene ID: ENSMUSG00000032601
  
Biological name :Prkar2a
  
Synonyms : Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha
  
Possible biological names infered from orthology : P13861 / protein kinase cAMP-dependent type II regulatory subunit alpha
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108689314
Gene end: 108750436
  
Corresponding Affymetrix probe sets: 10589087 (MoGene1.0st)   1427414_at (Mouse Genome 430 2.0 Array)   1428783_at (Mouse Genome 430 2.0 Array)   1432409_at (Mouse Genome 430 2.0 Array)   1452915_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035220
Ensembl peptide - ENSMUSP00000142251
Ensembl peptide - ENSMUSP00000141869
Ensembl peptide - ENSMUSP00000141517
NCBI entrez gene - 19087     See in Manteia.
MGI - MGI:108025
RefSeq - NM_008924
RefSeq Peptide - NP_032950
swissprot - A0A0A6YX73
swissprot - A0A0A6YWE5
swissprot - A0A0A6YY28
swissprot - Q8K1M3
Ensembl - ENSMUSG00000032601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar2aaENSDARG00000033184Danio rerio
 prkar2abENSDARG00000009477Danio rerio
 PRKAR2AENSGALG00000007023Gallus gallus
 P13861ENSG00000114302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*ENSMUSG0000000299768
Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*ENSMUSG0000002061236
P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*ENSMUSG0000002585536


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IEA
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttnmdm/Ttnmdm
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / complex / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / complex / reaction






 

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