ENSMUSG00000025855


Mus musculus

Features
Gene ID: ENSMUSG00000025855
  
Biological name :Prkar1b
  
Synonyms : P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta
  
Possible biological names infered from orthology : P31321 / protein kinase cAMP-dependent type I regulatory subunit beta
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 139017306
Gene end: 139150001
  
Corresponding Affymetrix probe sets: 10535053 (MoGene1.0st)   1416753_at (Mouse Genome 430 2.0 Array)   1416754_at (Mouse Genome 430 2.0 Array)   1434325_x_at (Mouse Genome 430 2.0 Array)   1440132_s_at (Mouse Genome 430 2.0 Array)   1440133_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106514
Ensembl peptide - ENSMUSP00000106515
Ensembl peptide - ENSMUSP00000123286
Ensembl peptide - ENSMUSP00000122693
Ensembl peptide - ENSMUSP00000121093
Ensembl peptide - ENSMUSP00000117412
Ensembl peptide - ENSMUSP00000116727
Ensembl peptide - ENSMUSP00000116022
Ensembl peptide - ENSMUSP00000026973
NCBI entrez gene - 19085     See in Manteia.
MGI - MGI:97759
RefSeq - XM_017320719
RefSeq - NM_001253890
RefSeq - NM_001359097
RefSeq - NM_001359098
RefSeq - NM_001359099
RefSeq - NM_001359100
RefSeq - NM_008923
RefSeq - XM_006504660
RefSeq - XM_006504661
RefSeq - XM_006504663
RefSeq Peptide - NP_032949
RefSeq Peptide - NP_001240819
RefSeq Peptide - NP_001346026
RefSeq Peptide - NP_001346027
RefSeq Peptide - NP_001346028
RefSeq Peptide - NP_001346029
swissprot - D3Z4A5
swissprot - D3Z406
swissprot - D3Z0V6
swissprot - P12849
swissprot - D3Z7E4
swissprot - D3Z068
swissprot - D3YTM5
swissprot - D3Z4L4
Ensembl - ENSMUSG00000025855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar1bENSDARG00000103800Danio rerio
 PRKAR1BENSGALG00000003675Gallus gallus
 P31321ENSG00000188191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*ENSMUSG0000002061282
Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*ENSMUSG0000003260138
P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*ENSMUSG0000000299738


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity ISO
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding ISO


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / complex / reaction
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr