ENSMUSG00000020612


Mus musculus

Features
Gene ID: ENSMUSG00000020612
  
Biological name :Prkar1a
  
Synonyms : Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / Q9DBC7
  
Possible biological names infered from orthology : P10644 / protein kinase cAMP-dependent type I regulatory subunit alpha
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 109649405
Gene end: 109669656
  
Corresponding Affymetrix probe sets: 10382284 (MoGene1.0st)   1425550_a_at (Mouse Genome 430 2.0 Array)   1447635_at (Mouse Genome 430 2.0 Array)   1452032_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056500
Ensembl peptide - ENSMUSP00000102287
Ensembl peptide - ENSMUSP00000102288
NCBI entrez gene - 19084     See in Manteia.
MGI - MGI:104878
RefSeq - NM_021880
RefSeq - XM_017314340
RefSeq - NM_001313973
RefSeq - NM_001313974
RefSeq - NM_001313975
RefSeq - NM_001313976
RefSeq - XM_006532509
RefSeq Peptide - NP_068680
RefSeq Peptide - NP_001300904
RefSeq Peptide - NP_001300905
RefSeq Peptide - NP_001300903
RefSeq Peptide - NP_001300902
swissprot - A2AI69
swissprot - Q9DBC7
Ensembl - ENSMUSG00000020612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar1abENSDARG00000101755Danio rerio
 Q5ZM91ENSGALG00000004237Gallus gallus
 P10644ENSG00000108946Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*ENSMUSG0000002585582
Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*ENSMUSG0000003260138
P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*ENSMUSG0000000299736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0007143 female meiotic nuclear division IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0045835 negative regulation of meiotic nuclear division IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation ISO
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0001772 immunological synapse ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005930 axoneme ISO
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex ISO
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044853 plasma membrane raft ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding ISO


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Ptentm1.1Mwst/Pten+,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001272 increased metastatic potential 
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ehmt1tm1Bzhu/Ehmt1tm1Bzhu,Ehmt2tm1Bzhu/Ehmt2tm1Bzhu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irf4m1Btlr/Irf4m1Btlr
Genetic Background: C57BL/6J-Irf4m1Btlr

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0003502 increased activity of thyroid 
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Ptentm1.1Mwst/Pten+,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0005470 increased thyroxine level "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0006002 abnormal small intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the small intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0008018 facial tumor "presence of abnormal, rapidly proliferating cells on the face usually in the form of a distinct mass " [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008293 abnormal zona glomerulosa morphology "any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced" [MESH:A06.407.071.140.960, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008297 retention of the x-zone "failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:3582592]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox10Dom/Sox10+
Genetic Background: C3Fe.B6JLe-Sox10Dom

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

 MP:0010079 osteochondroma "a benign cartilagenous neoplasm that consists of a pedicle of normal bone capped by a region of proliferating cartilage cells; most often associated with one or more of the long bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0010280 increased skeletal tumor incidence "greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010310 increased Schwannoma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Prkar1atm1.1Lsk/Prkar1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010346 increased thyroid carcinioma incidence "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

Allelic Composition: Prkar1atm1.2Lsk/Prkar1atm1.2Lsk,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prkar1atm1Gsm/Prkar1a+
Genetic Background: involves: 129X1/SvJ

 MP:0010971 abnormal periosteum morphology "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Tg(Bglap2-TAg)1Rkho/0,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lhx1tm2.1Bhr/Lhx1tm1Tmj,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011804 increased cell migration "increased or faster movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Prkar1atm1.2Lsk/Prkar1a+,Rb1tm2Brn/Rb1+,Tg(Col1a1-cre)1Kry/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
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Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012272 decreased axial mesoderm size "reduced size or deficiency of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012498 abnormal cardiogenic plate morphology "any structural anomaly of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [MGI:anna]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013579 increased adrenal gland apoptosis "increase in the number of any cells of the adrenal gland undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / reaction / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / reaction / complex






 

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